Article detail · 2025
Biological and Phytochemical Insights Into Opuntia ficus‐indica (L.) Mill: Cytotoxic, Wound‐Healing, and Anti‐Aging Potentials
Journal
Food Science & NutritionISSN 2048-7177
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2025
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Food Science & Nutrition
- Catalog match (ISSN) Food Science and Nutrition
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
ABSTRACT Opuntia ficus‐indica (L.) Mill. has cultivated wild forms in many parts of the world, attracting notably with its fruit. Its fruits can be eaten raw or processed. Studies have shown that fruit juice has various pharmacological effects and significant nutritional value. This study investigated the phenolic composition of O. ficus‐indica fruit juice. Caffeic acid was the major component. Cytotoxic activity and wound‐healing effect were evaluated by in vitro assays. Results showed a concentration‐dependent response, with the lowest viability (111.89% ± 17.90%) at 1000 μ g/mL and the highest (162.25% ± 7.48%) at 250 μ g/mL. The extract (0–250 μ g/mL) had comparable wound closure to the control group. It increased the lifespan of Caenorhabditis elegans , an in vivo model, at 125 μ g/mL. The binding potential of O. ficus‐indica to matrix metalloproteinase 13 (MMP‐13) and glycogen synthase kinase 3 β (GSK3‐β) was investigated for its wound‐healing effect. The phytoconstituents are bound to MMP‐13 and GSK3‐β, but less than the native ligands. They bound more to MMP‐13 than to GSK3‐β. Caffeic acid showed the highest binding potential with MMP‐13 and one of the highest with GSK3‐β. This study suggests that the wound‐healing and anti‐aging effects of O. ficus‐indica fruit juice can be promising.
Topics
Citations
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4 citations
OpenAlex cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Thermoresponsive gel delivery of caffeic acid promotes healing in a rat nasal septal perforation model 2025
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- Development and biological evaluation of a Cotinus coggygria extract-loaded Pluronic F127-HPMC buccal gel formulation 2026