Article detail · 2018
The effect of rutin on ovarian ischemia-reperfusion injury in a rat model
- Year
- 2018
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue GYNECOLOGICAL ENDOCRINOLOGY
- Catalog match (ISSN) Gynecological Endocrinology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
The effect of rutin on ovarian ischemia-reperfusion (I/R) injury was investigated in this experimental study. Eighteen Wistar albino female rats were divided into three groups as follows: I/R group (IRG; n = 6), 50 mg/kg rutin + I/R group (RG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). 2 h of ischemia and following 2 h of reperfusion were created in the IRG and RG by using a torsion model involving atraumatic vascular clips. Rutin, a flavonoid glycoside, was injected intraperitoneally at the dose of 50 mg/kg to RG group 1 h before reperfusion. Then, rats were euthanized and their ovaries were removed for biochemical and histopathological examination and also assessment of the gene expressions. IRG group had a significant increase in malondialdehyde (MDA) levels, in the expressions of tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and also in the activity of cyclooxygenase 2 (COX-2) unlike the significant decrease in total glutathione (tGSH) levels and the activity of COX-1 when compared to the SG group. However, rutin significantly decreased MDA levels, the expressions of TNF-α and IL-1β, and also the activity of COX-2 while it increased significantly tGSH levels and the activity of COX-1 in the RG group in comparison with the IRG group. Rutin ameliorated the I/R-induced ovarian injury in rats via its possible antioxidative and anti-inflammatory effects.
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Citations
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61 citations
OpenAlex cited_by_count (cache / database)
95 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Adalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation 2019
- Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats 2021
- Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats 2021
- The Effect of Lutein on Ischemia-reperfusion-induced Vasculitic Neuropathic Pain and Neuropathy in Rats 2021
- Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats 2021
- An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats 2019
- The propolis and boric acid can be highly suitable, alone/or as a combinatory approach on ovary ischemia-reperfusion injury 2019