Alcohol Consumption and Health Effects

Introduction Superoxide dismutases (SODs) are key antioxidant enzymes that neutralize superoxide radicals. Mammals express three isoforms: SOD1, SOD2, and SOD3. SOD1, a cytosolic copper-zinc enzyme encoded on chromosome 21q22, detoxifies reactive oxygen species. The gene has five exons and four introns, with notable v…

Aim: High-fructose corn syrup (HFCS) has been associated with metabolic and inflammatory disturbances, including pulmonary inflammatory injury. Due to its known anti-inflammatory and tissue-protective properties, this study aimed to investigate the protective effects of dexpanthenol (DEXP) against HFCS-induced structu…

Excessive intake of high-fructose corn syrup (HFCS) contributes to pediatric metabolic dysfunction-associated steatotic liver disease, but the mechanisms linking fructose exposure to inflammatory cell death remain incompletely defined. This study investigated whether dexpanthenol (DEX) attenuates HFCS-induced liver in…

Objectives: Opioid use has been associated with alterations in gut-brain axis signaling and intestinal barrier function. Zonulin, a key regulator of intestinal permeability, has been implicated in various neuropsychiatric and inflammatory conditions; however, its role in heroin addiction and remission remains poorly u…

Aim: The identification of alcohol and substance use disorders is primarily based on clinical evaluation, and the lack of accessible objective markers remains a challenge. This study aimed to explore whether routine hemogram parameters, analyzed using multiclass machine learning models, could assist in differentiating…

Toxic and hazardeus substances have negative effects on both the environment and human health. In this study, we aimed to determine the relationship between use of synthetic cannabinoids and complete blood count parameters, neutrophil/ lymphocyte ratio (NLR), platelet/eosinophil ratio (PER) and platelet/lymphocyte rat…

Fetal alcohol spectrum disorders (FASD) are associated with significant cardiac pathologies. In a compromised uterine environment, maternal stressors drive fetal adaptations that prioritize brain development, potentially at the expense of the heart. This study examined the role of the TRPM2 channel and its interaction…

Cervical carcinogenesis involves progressive molecular changes from preinvasive lesions to invasive carcinoma. Carboxypeptidase E (CPE) and aldehyde dehydrogenase 1A1 (ALDH1A1) have been implicated in cancer-related pathways, yet their stage-specific immunohistochemical expression patterns in cervical disease remain i…

Poisonings caused by methanol, ethylene glycol, and isopropanol are referred to as toxic alcohol poisonings. In this case report, we present a patient who presented to our emergency department approximately 10 hours after alcohol consumption with complaints of shortness of breath, altered mental status, and visual dis…

Poisonings caused by methanol, ethylene glycol, and isopropanol are referred to as toxic alcohol poisonings. In this case report, we present a patient who presented to our emergency department approximately 10 hours after alcohol consumption with complaints of shortness of breath, altered mental status, and visual dis…

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Hepatitis C virus (HCV) is a virus that can cause hepatitis, hepatic steatosis, cirrhosis and hepatocellular carcinoma. The distribution of HCV genotypes and subtypes varies according to geographical regions. The choice and duration of treatment for hepatitis C infection are influenced by genotype. This study aimed to…