Antimicrobial Peptides and Activities

Microbial bioactive peptides represent a promising class of natural compounds with significant potential as neuroprotective agents. Produced through fermentation, these peptides show antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory activities. Their ability to modulate the gut-brain axis further enh…

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The causative agent of American foulbrood, Paenibacillus larvae, is a leading cause of significant losses in beekeeping. In this study, the agent was isolated, its bacteriological characteristics were identified, and the expression levels of antibiotic resistance genes were determined. The study also assessed the anti…

Background Anticancer peptides (ACPs) are increasingly recognized as promising therapeutic candidates due to their ability to selectively target cancer cells. However, the systematic discovery of novel ACPs, particularly from high-throughput sequencing datasets, remains hindered by technical and methodological limitat…

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Penisilin bağlayan proteinler (PBP’ler), bakteriyel hücre duvarı sentezinin temel enzimleridir ve β-laktam antibiyotiklerin başlıca hedefini oluştururlar. PBP’ler, moleküler ağırlık ve enzimatik işlevlerine göre; çift işlevli sınıf A PBP’ler, yalnızca transpeptidaz aktivitesine sahip sınıf B PBP’ler ve düşük moleküler…

Bee venom (BV) is valued therapeutically mainly for its peptides, melittin and apamin. This study determined the dose-dependent biological activity of bee venom standardized to its melittin and apamin content by UHPLC-ESI-MS, as well as that of its principal peptides, melittin and apamin, tested at matched concentrati…

High Resolution Image Download MS PowerPoint Slide The bacterial ribosome is a key antibiotic target, yet peptide-based modulation from its functional and allosteric sites is underexplored. We developed a computational pipeline combining SiteMap-derived binding-site detection, consensus docking with Glide and rDock, a…

Abstract The increasing prevalence of antimicrobial resistance and biofilm-related infections represents a serious global health problem that limits the effectiveness of current therapeutic agents. Also, the increasing burden of cancer worldwide is one of the biggest challenges that we face. Both situations necessitat…

The increasing prevalence of antimicrobial resistance and biofilm-associated infections has intensified the search for alternative anti-infective strategies. Short peptide-based molecules have attracted growing interest due to their structural simplicity, biocompatibility, and multifunctional biological properties. In…

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