Article detail · 2017
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
- Year
- 2017
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Heterocyclic Communications
- Catalog match (ISSN) Heterocyclic Communications
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract The hydrazide 5 , that was obtained from 1-(4-fluorophenyl)piperazine ( 1 ), was converted to the corresponding carbothioamides 6a–c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a–f was performed via the intermediary of triazoles 7a–c . The condensation of triazoles 7a–c with several heterocyclic amines in the presence of formaldehyde afforded the corresponding N -aminoalkylated triazoles 11–14 . The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reactions was examined. The synthesized compounds were screened for their antimicrobial activities.
Topics
Citations
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25 citations
OpenAlex cited_by_count (cache / database)
23 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Novel imidazo[2,1-b][1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects 2019
- Novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects 2019
- Synthesis, biological activity and structure activity relationship studies of novel conazole analogues via conventional, microwave and ultrasound mediated techniques 2018
- Synthesis, biological activity and structure activity relationship studies of novel conazole analogues via conventional, microwave and ultrasound mediated techniques 2018
- Microwave‐Assisted Synthesis, Antioxidant, and Antimicrobial Evaluation of Piperazine‐Azole‐Fluoroquinolone Based 1,2,4‐Triazole Derivatives 2018
- Microwave‐Assisted Synthesis, Antioxidant, and Antimicrobial Evaluation of Piperazine‐Azole‐Fluoroquinolone Based 1,2,4‐Triazole Derivatives 2018
- Design, Microwave-Assisted and Conventional Synthesis of New Hybrid Compounds Derived From 1-(4-Fluorophenyl)piperazine and Screening for Their Biological Activities 2018
- Design, Microwave-Assisted and Conventional Synthesis of New Hybrid Compounds Derived From 1-(4-Fluorophenyl)piperazine and Screening for Their Biological Activities 2018
- Microwave-assisted Synthesis of Novel Mannich Base and Conazole Derivatives Containing Biologically Active Pharmacological Groups 2021
- Microwave-assisted Synthesis of Novel Mannich Base and Conazole Derivatives Containing Biologically Active Pharmacological Groups 2021