Article detail · 2008
Grape seed extract treatment reduces hepatic ischemia reperfusion injury in rats
- Year
- 2008
- DOI
- 10.1002/ptr.2256
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue PHYTOTHERAPY RESEARCH
- Catalog match (ISSN) Phytotherapy Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
This study was designed to determine the possible protective effect of grape seed extract (GSE), a widely used antioxidant dietary supplement, on hepatic ischemia/reperfusion (I/R) injury. Wistar albino rats were subjected to 45 min of hepatic ischemia, followed by a 60 min reperfusion period. GSE was administered in a dose of 50 mg/kg/day orally for 15 days before I/R injury and repeated before the reperfusion period. Liver samples were taken for histological examination or determination of hepatic malondialdehyde (MDA), glutathione (GSH) and myeloperoxidase (MPO) activity. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver functions. Lactate dehydrogenase (LDH) and cytokines (TNF-alpha and IL-1 beta) were also assayed in serum samples for the evaluation of generalized tissue damage. Ischemia/reperfusion caused a significant decrease in hepatic GSH, and significant increases in MDA level, and MPO activity. Serum AST and ALT levels, as well as LDH activity and plasma TNF-alpha and IL-1beta levels were also elevated in the I/R group. Treatment with GSE reversed all these biochemical parameters as well as histological alterations induced by I/R. In conclusion, GSE reduced I/R-induced organ injury through its ability to balance the oxidant-antioxidant status, to inhibit neutrophil infiltration and to regulate the release of inflammatory mediators.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
88 citations
OpenAlex cited_by_count (cache / database)
16 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats 2013
- The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats 2013
- The effect of grape seed extract on radiation-induced oxidative stress in the rat liver. 2008
- Effects of grape seed extract supplementation on exercise induced oxidative stress in rats 2012
- Effects of grape seed extract supplementation on exercise inducedoxidative stress in rats 2012
- Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats 2012
- The effects of ellagic acid on the liver and remote organs’ oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in rats. 2012
- The effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in rats. 2013
- The effects of ellagic acid on the liver and remote organs’ oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in rats 2012
- Nebivolol Ameliorates Hepatic Ischemia Reperfusion Injury on Liver But Not on Distant Organs 2015