Article detail · 2013
The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats
Journal
International Journal of SurgeryISSN 1743-9191
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2013
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue International Journal of Surgery
- Catalog match (ISSN) International Journal of Surgery (discontinued)
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
AIM: To investigate the protective effects of dexmedetomidine against hepatic ischemia/reperfusion (IR) injury and hepatic IR induced remote organ injury. METHODS: Forty Wistar albino rats were divided into the following four groups: sham, dexmedetomidine, IR, and IR + dexmedetomidine. Hepatic ischemia was created by the Pringle maneuver for 30 min followed by a 30 min reperfusion period in the IR and IR + dexmedetomidine groups. The dexmedetomidine and IR + dexmedetomidine groups were administered dexmedetomidine (100 μg/kg, single dose) intraperitoneally after the anesthesia insult. Blood samples and hepatic, renal, and lung tissue specimens were obtained to measure serum and tissue total oxidative activity (TOA), total antioxidant capacity (TAC), paraoxonase (PON-1), and oxidative stress index (OSI) after 60 min in all groups. RESULTS: According to the biochemical analyses of the samples taken from the serum and the liver, lung, and kidney tissues, when comparing the sham group and the IR group, TOA and OSI values were higher in the IR group, while TAC and PON-1 values were lower (p < 0.05). It was observed that TOA and OSI values were significantly lower, while TAC and PON-1 values increased with dexmedetomidine treatment (p < 0.05). In addition, dexmedetomidine ameliorated hepatic histopathological changes inducing IR, but there were no significant histopathological changes in the remote organs. CONCLUSION: This study demonstrated that dexmedetomidine markedly reduced the oxidative stress in serum, liver, and remote organs induced by hepatic IR injury, and ameliorated the histopathological damage in the liver.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
88 citations
OpenAlex cited_by_count (cache / database)
80 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- The comparison of neuroprotective effects of intrathecal dexmedetomidine and metilprednisolone in spinal cord injury 2013
- The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia reperfusion model formed with pringle maneuver in rats 2015