Synthesis and Characterization of Metal Complexes of 4-Nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide

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In this study, the new Fe(II) {[Fe(abt)2(SO4)].H2O (1)}, Ni(II) {[Ni(abt)2(Ac)2].4H2O (2)} and Cu(II) {[Cu(abt)2(Ac)2].4H2O (3)} complexes of 4-nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (abt) were synthesized. The structures (1-3) were suggested by elemental analysis, AAS, molar conductivity, and magnetic susceptibility methods. As a consequence of spectroscopic evaluation, it was determined that compounds 1-3 exhibited a non-ionic and tetrahedral conformation. A comprehensive examination was conducted on the susceptibility of all substances to C. albicans (yeast), E. faecalis, E. coli, L. monocytogenes, S. aureus, P. aeruginosa, and B. subtilis (bacteria) were thoroughly investigated. The antimicrobial activities were contrasted with those of Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin, and Cefepime. Compounds abt and 2 showed better activity in S. aureus and B. subtilis bacteria, while compounds 1-3 showed the same activity in E. coli and E. faecalis bacteria and C. albicans yeast. Complex 3 showed better activity in L. monocytogenes bacteria.