Protective effects of safranal against subchronic thinner inhalation induced oxidative stress in rats

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This study was carried out to determine the effects of subchronic thinner inhalation on the oxidant− antioxidant balance,the relation between toxicity and oxidative stress, and a possible protective effect of α-lipoic acid against thinner toxicationin rats. Sprague−Dawley rats were divided into 4 groups as follows: control (Gr. I), safranal (Gr. II), thinner (Gr. III), andthinner+safranal Gr. IV). Each group consisted of 10 rats, and the study lasted for 8 weeks. After completing the animalstudies malondialdehyde (MDA), reduced glutathione (GSH), toluol, 8OHdG (8 hydroxy 2 deoxyguanosine), proteinoxidation, nitric oxide metabolites (NOx), total antioxidant capacity (TAC), total oxidant capacity (TOC), glucose, totalcholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, WBC, VLDL, RBC, HCT, Hb, aspartate amino transferase(AST), and alanine amino transferase (ALT) levels were determined from blood specimens of the rats. Brain and lungtissues were also examined histopathologically. The data obtained from the study were statistically analyzed using SPSS,and both ANCOVA and Bonferroni tests were performed. P <0.05 was accepted as statistically significant. The resultsindicated that safranal had a protective and balancing effect against thinner inhalation oriented complications in rats.