Article detail · 2009
Determination of Polyphenolic Constituents And Biological Activities of Bark Extracts From Different Pinus Species
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
- Catalog match (ISSN) Journal of the Science of Food and Agriculture
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract BACKGROUND: The most common commercially available pine bark extract is Pycnogenol®, a standardised extract of Pinus maritima, which has been reported to have cardiovascular benefits and enhance microcirculation. The present study was conducted to determine the chemical composition of four pine bark extracts, assess their biological activities and to compare the results with Pycnogenol®. RESULTS: The Pinus species were analysed by LC and LC‐MS; extracts of P. brutia and P. nigra showed higher levels of phenolic constituents compared to P. sylvestris and P. pinea. In particular, P. brutia contained extremely high concentrations of taxifolin (18.5%). The highest radical scavenging activities were attained with P. pinea (88.6%), P. nigra (87.2%) and P. brutia (86.4%) bark extracts. Additionally, anticarcinogenic effects of the extracts and their kinetics were determined in four cell lines including human prostate (PC‐3, DU 145, LNCaP) and breast adenocarcinoma (MCF7) by the MTT assay. Cell viability was reduced to 40% by extracts of P. pinea, and P. sylvestris in PC‐3 cells showing a similar effect like the positive control, CPT‐11. CONCLUSION: Pinus species other than P. maritima definitively possess high biological activities, and therefore present a huge potential to be utilised in the food and the pharmaceutical industries. Copyright © 2009 Society of Chemical Industry
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Citations
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75 citations
OpenAlex cited_by_count (cache / database)
35 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Characterization of Pinus brutia bark tannin by MALDI-TOF MS and 13C NMR 2013
- Characterization of Pinus brutia bark tannin by MALDI TOF MS and 13C NMR 2013
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- Extracts from Black Carrot Tissue Culture as Potent Anticancer Agents 2013
- Extracts from Black Carrot Tissue Culture as Potent Anticancer Agents 2013
- Extracts from Black Carrot Tissue Culture as Potent Anticancer Agents 2013
- Extracts from Black Carrot Tissue Culture as Potent Anticancer Agents 2013
- Determination of Antioxidant Activity of Different Extracts From Bark of Pinus spp. grown in Giresun (Turkey) Province – Phenolic analysis by RP-HPLC-DAD 2022
- Determination of phenolic content of different bark extracts from three Pinus spp. grown in Giresun (Turkey) Province by HPLC-DAD and investigation of their antioxidant activities 2022
- Determination of phenolic content of different bark extracts from three Pinus spp. grown in Giresun (Turkey) Province by HPLC-DAD and investigation of their antioxidant activities 2022