Article detail · 2008
Melatonin Protects Myocardium from Ischemia Reperfusion Injury in Hypertensive Rats Role of Myeloperoxidase Activity
- Year
- 2008
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Clinical and Experimental Hypertension
- Catalog match (ISSN) Clinical and Experimental Hypertension
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Increased levels of reactive oxygen species, alterations in nitric oxide synthesis, and increased migration of neutrophils to the ischemic tissue play an important role in the pathophysiology of myocardial ischemia-reperfusion (IR) injury. In this study, we have evaluated the effects of melatonin on myeloperoxidase (MPO) activity, tissue glutathione (GSH), lipid peroxidation levels, and blood pressure in L-NAME-induced hypertensive rats with or without IR. NOS inhibitor L-NAME was administrated before inducing cardiac ischemia for 15 days intraperitoneally. For the cardiac ischemia, the left coronary artery was ligated for 30 min, and reperfusion was performed for 120 min after the ischemia. L-NAME treatment in non-ischemic animals increased blood pressure and lipid peroxidation, and decreased glutathione level in myocardial tissue significantly as compared with non-L-NAME-treated animals. Melatonin reversed L-NAME-induced blood pressure elevation and oxidative changes. Cardiac IR increased MDA levels and MPO activity and decreased GSH levels as compared with non-ischemic animals. L-NAME treatment did not change in IR-induced MDA and GSH levels as compared with ischemic control animals. However, MPO activity was significantly higher than control ischemic animals. MDA levels and MPO activity resulting from ischemic injury in melatonin-treated animals were significantly less than L-NAME-treated animals. Taken together-the ischemic and non-ischemic control and melatonin-treated animals-this study shows that neutrophil migration plays an important role on the development of ischemic injury in hypertensive rats.
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Citations
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32 citations
OpenAlex cited_by_count (cache / database)
19 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension 2009
- Role of propolis on biochemical parameters in kidney and heart tissues against scp l scp NAME induced oxidative injury in rats title 2014
- Role of propolis on biochemical parameters in kidney and heart tissues againstl-NAME induced oxidative injury in rats 2014
- Role of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in rats 2014
- Role of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase Inhibited Hypertensive Rats 2012
- Role of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase Inhibited Hypertensive Rats 2012
- Propolis reduces oxidative stress in l ‐NAME‐induced hypertension rats 2013
- Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats 2015
- Antioxidant effect of ethanolic extract of propolis in liver of L-NAME treated rats 2015
- Physiological and pharmacological effects of melatonin on remote ischemic perconditioning after myocardial ischemia‐reperfusion injury in rats: Role of Cybb, Fas, NfκB, Irisin signaling pathway 2019