Article detail · 2012
Role of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase Inhibited Hypertensive Rats
- Year
- 2012
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Clinical and Experimental Hypertension
- Catalog match (ISSN) Clinical and Experimental Hypertension
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Reduction in the synthesis or bioavailability of nitric oxide plays a significant role in the development of hypertension. Propolis is a resinous product collected by honeybees from various plant sources. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. The aim of this study was to examine the effect of propolis on blood pressure (BP), TH, and total RNA levels in the adrenal medulla, heart, and hypothalamus tissues in chronic nitric oxide synthase (NOS)-inhibited rats by N(w)-nitro-l-arginine methyl ester (L-NAME). Rats received NOS inhibitor (L-NAME) for 15 days to produce hypertension and propolis for the last 5 days. TH activity and total RNA levels significantly increased in adrenal medulla, heart, and hypothalamus tissues in L-NAME-treated groups (P < .05). TH activity and total RNA levels of L-NAME+propolis-treated rats reduced (P < .05) compared with L-NAME-treated groups. TH activity in propolis-treated rats was reduced to the control values. L-NAME led to a significant increase in BP compared with the control group. Propolis administration to L-NAME-treated rats reduced BP but this was not statistically significant compared to L-NAME-treated groups. These results suggest that propolis decreases TH activity in NOS-inhibited hypertensive rats and thereby may modulate the synthesis of catecholamine and BP.
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Citations
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50 citations
OpenAlex cited_by_count (cache / database)
19 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach 2017
- Role of propolis on biochemical parameters in kidney and heart tissues against scp l scp NAME induced oxidative injury in rats title 2014
- Role of propolis on biochemical parameters in kidney and heart tissues againstl-NAME induced oxidative injury in rats 2014
- Role of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in rats 2014
- Propolis reduces oxidative stress in l ‐NAME‐induced hypertension rats 2013
- Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats 2015
- Antioxidant effect of ethanolic extract of propolis in liver of L-NAME treated rats 2015
- Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L NAME Treated Rats 2015
- The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via N omega-nitro-L-arginine methyl ester 2021
- The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester 2021