Article detail · 2018
Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression
- Year
- 2018
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Pharmaceutical Analysis
- Catalog match (ISSN) Journal of Pharmaceutical Analysis
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R. canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer (WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
58 citations
OpenAlex cited_by_count (cache / database)
46 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- A new highly active polymer supported ruthenium nanocatalyst for the hydrolytic dehydrogenation of dimethylamine-borane 2019
- Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells 2020
- title iRosa canina/i Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells/title 2020
- title iRosa canina/i Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells/title 2020
- Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells 2020
- Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells 2020
- Dorycnium pentaphyllum Extract Has Antiproliferative Effect on Human Cervix and Colon Cancer Cells 2020
- Effects of topiramate on adipocyte differentiation and gene expression of certain carbonic anhydrase isoenzymes 2020
- Dorycnium pentaphyllum Extract Has Antiproliferative Effect on Human Cervix and Colon Cancer Cells 2019
- Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells 2021