Makale detayı · 2018
Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression
- Yıl
- 2018
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Pharmaceutical Analysis
- Katalog eşleşmesi (ISSN) Journal of Pharmaceutical Analysis
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R. canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer (WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.
Konular
Atıflar
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58 atıf
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Yerel katalogda bu makaleye atıf yapan 46 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- title iRosa canina/i Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells/title 2020
- title iRosa canina/i Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells/title 2020
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