Article detail · 2015 · article
Overexpression of miR-145\u20135p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression
Data source split
- YÖKSİSYÖKSİS article record
- YÖKSİS venueCancer Investigation
- Catalog match (ISSN)Cancer Investigation
- OpenAlexOpenAlex enrichment (abstract, citations, topics)
- Semantic Scholarcitation count (not merged with OpenAlex)
Abstract
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
87citationsOpenAlex · cited_by_count (cache / database)
23 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- 2017 miR-33a is a tumor suppressor microRNA that is decreased in prostate cancerCitations 43 · OpenAlex
- 2017 miR-33a is a tumor suppressor microRNA that is decreased in prostate cancerCitations 43 · OpenAlex
- 2019 MicroRNAs as prognostic markers in prostate cancerCitations 34 · OpenAlex
- 2019 MicroRNAs as prognostic markers in prostate cancerCitations 34 · OpenAlex
- 2018 MicroRNAs as prognostic markers in prostate cancerCitations 34 · OpenAlex
- 2016 A Meta Analysis Identification of Common Mir 145 Target Genes that have Similar Behavior in Different GEO DatasetsCitations 28 · OpenAlex
- 2016 A Meta-Analysis: Identification of Common Mir-145 Target Genes that have Similar Behavior in Different GEO DatasetsCitations 28 · OpenAlex
- 2016 A Meta-Analysis: Identification of Common Mir-145 Target Genes that have Similar Behavior in Different GEO DatasetsCitations 28 · OpenAlex
- 2021 miR-145 suppresses epithelial-mesenchymal transition by targeting stem cells in Ewing sarcoma cellsCitations 15 · OpenAlex
- 2020 Mode of action of carboplatin via activating p53/miR\u2010145 axis in head and neck cancersCitations 14 · OpenAlex