Article detail · 2021
Design, synthesis, characterization and in vitro cytotoxic activity evaluation of 1,2-disubstituted benzimidazole compounds
- Year
- 2021
- DOI
- 10.1002/poc.4125
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
- Catalog match (ISSN) Journal of Physical Organic Chemistry
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract A series of 2‐p‐tolyl‐1H‐benzo[d]imidazole derivatives were synthesized and characterized. For finding an effective anticancer drug, which could be used in future generations, the developed heterocyclic compounds were screened in the human epithelial breast adenocarcinoma cell line (MCF‐7) and human liver epithelial hepatocellular carcinoma cell line (HepG2) using the MTT assay method. Two positive control drugs were used for comparison with the compounds. The substituents on the 1‐ and 2‐positions of the benzimidazole core had an important effect on the antiproliferation of cancerous cells. According to the results obtained, a compound, namely, 1‐(4‐methylbenzyl)‐2‐p‐tolyl‐1H‐benzo[d]imidazole, which has electron donating groups (CH3) in the para position of a phenyl ring, showed higher cytotoxic activities compared to other compounds towards liver and breast cell lines. The compounds were found to have more cytotoxicity in HepG2 rather than MCF‐7.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
26 citations
OpenAlex cited_by_count (cache / database)
52 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Recent advances in the application of heterogeneous catalysts for the synthesis of benzimidazole derivatives 2024
- Recent Advances in the Anticancer Applications of Benzimidazole Derivatives 2023
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