Article detail · 2011
Protein and DNA Oxidation in Different Anatomic Regions of Rat Brain in a Mimetic Ageing Model
Journal
BASIC CLINICAL PHARMACOLOGY TOXICOLOGYISSN 1742-7835
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2011
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue BASIC CLINICAL PHARMACOLOGY TOXICOLOGY
- Catalog match (ISSN) Basic and Clinical Pharmacology and Toxicology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
It has been reported that d-galactose administration causes an increase in oxidative and osmotic stresses in several tissues of rodents. In this study, we established a brain ageing model by using d-galactose and investigated the concentrations of oxidative stress markers on the hippocampus, parietal and frontal lobes of male Sprague-Dawley rats. A mimetic ageing model was established by injecting d-galactose (60 mg/kg/day/i.p.) in the experimental group for 42 days. At the end of this period, we tested spatial memory using the Morris water maze test. To investigate the magnitude of oxidative damage in proteins, lipids and DNA, we studied the concentrations of various oxidative stress parameters in the hippocampus, parietal and frontal lobes of the brain. Glial and neuronal cell oxidative damage was observed in each of the three anatomic regions. It was found that protein carbonyl groups and advanced oxidation product concentrations in the d-galactose applied group were significantly high in each of the three brain lobes compared with the control group. Thiol concentration was found to be decreased in the parietal lobe. A concurrent increase in lipid hydroperoxides was also observed in this lobe. On the other hand, 8-hydroxy-2'-deoxyguanosine concentration was significantly increased in the hippocampal lobe of rats in the experimental group when compared with the controls. The results obtained from the mimetic ageing model rats showed that various anatomical regions of brain have different susceptibility to oxidative damage of proteins, lipids and DNA.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
81 citations
OpenAlex cited_by_count (cache / database)
17 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Human Serum Albumin and Its Relation with Oxidative Stress 2013
- A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats 2014
- A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats 2014
- A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats 2014
- Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level 2014
- Ameliorative Effects of Testosterone Administration on Renal Redox Homeostasis in Naturally Aged Rats 2015
- Ameliorative Effects of Testosterone Administration on Renal Redox Homeostasis in Naturally Aged Rats 2015
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