Article detail · 2005
Erythropoietin Increases Glutathione Peroxidase Enzyme Activity and Decreases Lipid Peroxidation Levels in Hypoxic Ischemic Brain Injury in Neonatal Rats
- Year
- 2005
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Neonatology
- Catalog match (ISSN) Neonatology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: We have previously shown that erythropoietin (Epo) exerts neuroprotective effects in the Rice-Vannucci model of neonatal hypoxic-ischemic brain injury. However, the mechanisms of Epo protection in this model are still unclear. OBJECTIVES: In the present study, we studied the effects of systemically administered Epo on lipid peroxidation levels and antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities following hypoxic-ischemic brain injury in neonatal rats. METHODS: Seven-day-old Wistar rat pups were subjected to left carotid artery occlusion followed by 2.5 h of hypoxic exposure. Brain lipid peroxidation levels and antioxidant enzyme activities were measured in the injured hemispheres 24 h after the hypoxic-ischemic insult. RESULTS: Hypoxic-ischemic injury significantly increased the thiobarbituric acid-reactive substance levels in the injured hemispheres as compared to the control group. In addition, glutathione peroxidase activity was significantly elevated in Epo-treated animals compared to saline-treated animals and the control group. CONCLUSIONS: These results suggest that Epo exerts neuroprotective effects against hypoxic-ischemic brain injury at least partially via the modulation of antioxidant enzyme activity.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
122 citations
OpenAlex cited_by_count (cache / database)
32 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Erythropoietin Attenuates Lipopolysaccharide-Induced White Matter Injury in the Neonatal Rat Brain 2007
- Activated protein C reduces endotoxin induced white matter injury in thedeveloping rat brain 2007
- NOVEL EVIDENCE SUGGESTING AN ANTI OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN INDUCED NEPHROTOXICITY IN A RAT MODEL 2007
- NOVEL EVIDENCE SUGGESTING AN ANTI OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN INDUCED NEPHROTOXICITY IN A RAT MODEL 2007
- Protective effects of erythropoietin against ethanol induced apoptotic neurodegenaration and oxidative stress in the developing C57BL 6 mouse brain 2005
- Zinc Supplementation Ameliorates Electromagnetic Field Induced Lipid Peroxidation in the Rat Brain 2006
- Erythropoietin in neonatal brain protection The past the present and the future 2011
- Erythropoietin in neonatal brain protection The past the present and the future 2011
- Protective effect of erythropoietin pretreatment in testicular ischemia reperfusion injury in rats 2008
- Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats 2017