Article detail · 2007
NOVEL EVIDENCE SUGGESTING AN ANTI OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN INDUCED NEPHROTOXICITY IN A RAT MODEL
- Year
- 2007
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Clinical and Experimental Pharmacology and Physiology
- Catalog match (ISSN) Clinical and Experimental Pharmacology and Physiology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
1. The aim of the present study was to investigate the role of oxidative stress in renal injury and to determine whether erythropoietin (EPO) acts as an anti-oxidant in vancomycin (VCM)-induced renal impairment. 2. Twenty-four rats were divided into three groups as follows: (i) control (Group 1); (ii) VCM treated (Group 2); and (iii) VCM + EPO treated (Group 3). Vancomycin (200 mg/kg, i.p.) was administered to Groups 2 and 3 for 7 days. Erythropoietin (150 IU/kg, i.p.) treatment was started 24 h before VCM and lasted for 7 days. On Day 8, renal tissues were excised and blood samples were collected. Serum creatinine and blood urea nitrogen were measured, along with renal malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activity and tissue VCM levels. The kidneys were examined for any histopathological changes. 3. Renal MDA levels were found to be increased, whereas SOD and CAT activity was decreased, in the VCM-treated group compared with the control group. There was a marked decrease in MDA levels and an increase in SOD activity, but not CAT activity, after VCM + EPO treatment. Marked histopathological alterations, including interstitial oedema, tubular dilatation, tubular epithelial cell desquamation and vacuolization, were observed in VCM-treated rats. Histopathological changes were significantly improved after EPO administration. 4. In conclusion, the present data suggest that oxidative stress plays an important role in VCM-induced nephrotoxicity. Erythropoietin seems to act as an anti-oxidant, diminishing the toxic oxidative effects of VCM on renal tissues.
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81 citations
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17 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Protective effects of Thymoquinone on vancomycin induced nephrotoxicity in rats 2012
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats 2020
- Amikacin induced renal damage and the role of the antioxidants on neonatal rats 2016
- Amikacin induced renal damage and the role of the antioxidants on neonatal rats 2016
- Amikacin induced renal damage and the role of the antioxidants on neonatal rats 2016
- Role of erythropoietin in prevention of amikacin induced nephropathy 2012
- Role of erythropoietin in prevention of amikacin induced nephropathy 2012
- The Effect of Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, on Vancomycin-Induced Nephrotoxicity in Rats. 2025