Article detail · 2015
Sickle cell detection using a smartphone
- Year
- 2015
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Scientific Reports
- Catalog match (ISSN) Scientific Reports
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Sickle cell disease affects 25% of people living in Central and West Africa and, if left undiagnosed, can cause life threatening "silent" strokes and lifelong damage. However, ubiquitous testing procedures have yet to be implemented in these areas, necessitating a simple, rapid, and accurate testing platform to diagnose sickle cell disease. Here, we present a label-free, sensitive, and specific testing platform using only a small blood sample (<1 μl) based on the higher density of sickle red blood cells under deoxygenated conditions. Testing is performed with a lightweight and compact 3D-printed attachment installed on a commercial smartphone. This attachment includes an LED to illuminate the sample, an optical lens to magnify the image, and two permanent magnets for magnetic levitation of red blood cells. The sample is suspended in a paramagnetic medium with sodium metabisulfite and loaded in a microcapillary tube that is inserted between the magnets. Red blood cells are levitated in the magnetic field based on equilibrium between the magnetic and buoyancy forces acting on the cells. Using this approach, we were able to distinguish between the levitation patterns of sickle versus control red blood cells based on their degree of confinement.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
127 citations
OpenAlex cited_by_count (cache / database)
51 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- 3D-printed microneedles in biomedical applications 2021
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- 3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs 2016
- 3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry 2017
- Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering 2018
- 3D bioprinted organ‐on‐chips 2022
- Recent Advances in Magnetic Levitation: A Biological Approach from Diagnostics to Tissue Engineering 2018
- Label-Free Sickle Cell Disease Diagnosis using a Low-Cost, Handheld Platform 2016
- Self-Contained Handheld Magnetic Platform for Point of Care Cytometry in Biological Samples 2016
- Biomedical Applications of Magnetic Levitation 2021