Makale detayı · 2015
Sickle cell detection using a smartphone
- Yıl
- 2015
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Scientific Reports
- Katalog eşleşmesi (ISSN) Scientific Reports
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Sickle cell disease affects 25% of people living in Central and West Africa and, if left undiagnosed, can cause life threatening "silent" strokes and lifelong damage. However, ubiquitous testing procedures have yet to be implemented in these areas, necessitating a simple, rapid, and accurate testing platform to diagnose sickle cell disease. Here, we present a label-free, sensitive, and specific testing platform using only a small blood sample (<1 μl) based on the higher density of sickle red blood cells under deoxygenated conditions. Testing is performed with a lightweight and compact 3D-printed attachment installed on a commercial smartphone. This attachment includes an LED to illuminate the sample, an optical lens to magnify the image, and two permanent magnets for magnetic levitation of red blood cells. The sample is suspended in a paramagnetic medium with sodium metabisulfite and loaded in a microcapillary tube that is inserted between the magnets. Red blood cells are levitated in the magnetic field based on equilibrium between the magnetic and buoyancy forces acting on the cells. Using this approach, we were able to distinguish between the levitation patterns of sickle versus control red blood cells based on their degree of confinement.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
127 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 52 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Utilizing stem cells for three-dimensional neural tissue engineering 2016
- 3D-printed microneedles in biomedical applications 2021
- 3D-printed microneedles in biomedical applications 2021
- 3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs 2016
- 3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry 2017
- Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering 2018
- 3D bioprinted organ‐on‐chips 2022
- Recent Advances in Magnetic Levitation: A Biological Approach from Diagnostics to Tissue Engineering 2018
- Label-Free Sickle Cell Disease Diagnosis using a Low-Cost, Handheld Platform 2016
- Self-Contained Handheld Magnetic Platform for Point of Care Cytometry in Biological Samples 2016