Article detail · 2022
Effect of Calix[4]arene as a Hydrophobic Substituent on Proline Catalysis of Direct Asymmetric Aldol Reactions in the Presence of Water
Russian Journal of General Chemistry
- Year
- 2022
- ISSN
1070-3632- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
Abstract A new organocatalyst trans-4-hydroxy-L-proline-derived calix[4]arene was synthesized and its catalyst performance for the direct asymmetric aldol reactions between cyclohexanone and different aromatic aldehydes was investigated. The effect of a series of reaction conditions such as solvent, water and additives were evaluated in detail, and it was observed that the addition of water had a big effect on the enantioselectivities. Specifically, high anti-diastereoselectivity (anti/syn = 92 : 8) and high enantioselectivity (ee 88%) were obtained from the reaction between cyclohexanone and 4-fluorobenzaldehyde in the presence of water.
Topics
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
Primary topic Asymmetric Synthesis and Catalysis