Article detail · 2018
Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans after single intravenous and intramuscular injections
- Year
- 2018
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Veterinary Pharmacology and Therapeutics
- Catalog match (ISSN) Journal of Veterinary Pharmacology and Therapeutics
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red‐eared slider turtles. Plasma concentrations of CFQ were determined by high‐performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half‐life (t1/2λz) 21.73 ± 4.95 hr, volume of distribution at steady‐state (Vdss) 0.37 ± 0.11 L/kg, area under the plasma concentration–time curve (AUC0–∞) 163 ± 32 μg hr−1 ml−1, and total body clearance (ClT) 12.66 ± 2.51 ml hr−1 kg−1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (Cmax) 3.94 ± 0.84 μg/ml, time to peak concentration (Tmax) 3 hr, t1/2λz 26.90 ± 4.33 hr, and AUC0–∞ 145 ± 48 μg hr−1 ml−1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half‐life and a high bioavailability in red‐eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.
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Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
7 citations
OpenAlex cited_by_count (cache / database)
5 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans) 2019
- Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans) 2019
- Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans) 2019
- Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep 2025
- Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep 2025