Makale detayı · 2018
Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans after single intravenous and intramuscular injections
- Yıl
- 2018
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Veterinary Pharmacology and Therapeutics
- Katalog eşleşmesi (ISSN) Journal of Veterinary Pharmacology and Therapeutics
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red‐eared slider turtles. Plasma concentrations of CFQ were determined by high‐performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half‐life (t1/2λz) 21.73 ± 4.95 hr, volume of distribution at steady‐state (Vdss) 0.37 ± 0.11 L/kg, area under the plasma concentration–time curve (AUC0–∞) 163 ± 32 μg hr−1 ml−1, and total body clearance (ClT) 12.66 ± 2.51 ml hr−1 kg−1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (Cmax) 3.94 ± 0.84 μg/ml, time to peak concentration (Tmax) 3 hr, t1/2λz 26.90 ± 4.33 hr, and AUC0–∞ 145 ± 48 μg hr−1 ml−1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half‐life and a high bioavailability in red‐eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.
Konular
Atıflar
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Yerel katalogda bu makaleye atıf yapan 5 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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