Article detail · 2018 · article
Effects of aryl methanesulfonate derivatives on acetylcholinesterase and butyrylcholinesterase
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- YÖKSİSYÖKSİS article record
- YÖKSİS venueJournal of Biochemical and Molecular Toxicology
- Catalog match (ISSN)Journal of Biochemical and Molecular Toxicology
- OpenAlexOpenAlex enrichment (abstract, citations, topics)
- Semantic Scholarcitation count (not merged with OpenAlex)
Abstract
Abstract There is a dire need for new treatments for Alzheimer's disease (AD). Principal drugs have reached maturity, and the number of people affected by AD is growing at a rapid rate. After years of research and many clinical trials, only symptomatic treatments are available. An effective disease‐modifying drug for AD needs to be discovered. The research presented in this paper aims to facilitate in the discovery of new potential targets that could help in the ongoing AD research. Aryl methanesulfonate derivatives were screened for their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. IC50 values between 0.660 and 3.397 µM against AChE and 0.885 and 2.596 µM against BuChE were obtained.
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Citations
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28citationsOpenAlex · cited_by_count (cache / database)
55 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- 2019 Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studiesCitations 117 · OpenAlex
- 2019 Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studiesCitations 117 · OpenAlex
- 2019 Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studiesCitations 117 · OpenAlex
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- 2019 Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition studyCitations 44 · OpenAlex
- 2019 Triazole Substituted Metal-Free and Metallophthalocyanines and Their Water Soluble Derivatives as Potential Cholinesterases Inhibitors for the Treatment of Alzheimer’xxs Disease: Design, Synthesis, and in vitro Inhibition StudyCitations 44 · OpenAlex
- 2019 Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition studyCitations 44 · OpenAlex