Horizon Europe · Global Challenges and European Industrial Competitiveness
An AI Foundation Toxicology Model and Framework to Support Waiving a Second Species in Drug Safety Studies
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From the official text, opening part
Expected Impact: The action under this topic is expected to achieve the following impacts: Faster and more informed decision-making through the use of an AI-driven NAM (AI Foundation Toxicology Model) and increased efficiency through rapid processing of vast amounts of data [1] . Increased consistency and standardisation in a NAM-based approach, specifically an AI model, used by industry in the efficient development, testing and production of safe and effective innovative health technologies, improving industrial competitiveness. Regulatory adoption of a NAM-enabled second species waiver model (AI Foundation Toxicology Model) and weight-of-evidence framework, in line with recommendations and more consistent global decision-making on waiving second species testing. Reduction in animal use, accelerated timelines and lower costs, enhancing the competitiveness of the European health industry… more
Animal welfareArtificial Intelligence & Decision supportArtificial intelligenceSafety PharmacologyToxicologyAn AI Foundation Toxicology Model and Framework to Support Waiving a Second Species in Drug Safety StudiesIHIIHI JUInnovative Health InitaitiveInnovative Health Initaitive Joint UndertakingJoint Undertaking
Academics who may be relevant
By subject fit
30-
%56ABBAS GÜNGÖRDÜ
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Developmental, toxicological effects and recovery patterns in Xenopus laevis after exposure to penconazole-based fungicide during the metamorphosis process (2022) · Comparative evaluation of toxicological effects and recovery patterns in zebrafish ( Danio rerio ) after exposure to phosalone-based and cypermethrin-based pesticides (2018)
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%51MUHAMMED ATAMANALP
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: May PdCu@f-MWCNT NPs be an ecotoxicologic risk? (2023) · Toxicological Assessment of Melamine‐Functionalized Graphene Oxide and Carbon Nanotubes Using Zebrafish Models (2025)
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%50BURAK KAPTANER
Shared topics: Reproductive biology and impacts on aquatic species · Environmental Toxicology and Ecotoxicology
Overlapping papers: Toxicological investigation of bisphenol A and its derivates on human breast epithelial (MCF-10A) cells (2025) · Immunohistochemical distribution of insulin-, glucagon- and somatostatin-containing cells in the pancreas of Lake Van fish (Alburnus tarichi Güldenstädt, 1814) (Cyprinidae) (2019)
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%49AHMET REGAİB OĞUZ
Shared topics: Environmental Toxicology and Ecotoxicology · Reproductive biology and impacts on aquatic species
Overlapping papers: Investigation of some hormones affecting osmoregulation of Lake Van fish (Alburnus tarichi) during reproductive migration (2022) · Investigation of some hormones affecting osmoregulation of Lake Van fish ( Alburnus tarichi ) during reproductive migration (2021)
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%49HATİCE ASLI BEDEL
Research topics: Artificial Intelligence in Healthcare and Education · Insect and Pesticide Research · Clinical Reasoning and Diagnostic Skills
Overlapping papers: Emergency Medicine Assistants in the Field of Toxicology, Comparison of ChatGPT-3.5 and GEMINI Artificial Intelligence Systems (2024)
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%49PELİN UĞURLU
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: The toxicological effects of thiamethoxam on Gammarus kischineffensis Schellenberg 1937 Crustacea Amphipoda (2015) · Scanning electron microscopy study of the gills scales and erythrocytes of Anabas testudineus upon exposure to chlorpyrifos (2015)
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%49SONIA SANAJOU
Shared topics: Pesticide Residue Analysis and Safety
Overlapping papers: Safety and possible risks of tea tree oil from a toxicological perspective (2024) · Dental Implants and Implant Coatings: A Focus on Their Toxicity and Safety (2023)
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%47CANSU AKBULUT
Shared topics: Environmental Toxicology and Ecotoxicology · Reproductive biology and impacts on aquatic species
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%47NEBİLE DAĞLIOĞLU
Shared topics: Forensic Toxicology and Drug Analysis
Overlapping papers: Toxicological Analysis of Warfarin in an Adult Developing Diffuse Alveolar Hemorrhage: A Case Report and Literature Review (2020) · New Psychoactive Substance 5-MeO-MIPT In vivo Acute Toxicity and Hystotoxicological Study (2020)
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%47VOLKAN KORKMAZ
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: The Effect of Gadolinium and Lanthanum on the Mortality of Daphnia magna (2021) · Comparative evaluation of toxicological effects and recovery patterns in zebrafish ( Danio rerio ) after exposure to phosalone-based and cypermethrin-based pesticides (2018)
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%46DEMET DOĞAN
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Water Quality and Heavy Metal Pollution in Kayacik Dam (Gaziantep, Turkey) (2020) · Pro-oxidant potency of clothianidin in rainbow trout (2021)
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%46ERGÜN ERGENEKON
Shared topics: Environmental Toxicology and Ecotoxicology
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%46GÜLÇİN TUĞCU
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: In silico and in vitro evaluation of the potential genotoxic impurities of vildagliptin (2025) · Toxicological evaluation of ergocalciferol, cholecalciferol, and their metabolites by a category approach (2019)
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%46VEYSİ KIZMAZ
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Determination of fatty acids of phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol and phosphatidylserine from the cephalopedal and total body of edible snail Helix lucorum (2015) · FATTY ACID ANALYSIS FOR SEEDS OF SOME ORCHID SPECIES SPREADING IN VAN PROVINCE (2021)
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%46ÖZLEM DEMİRCİ TURGUNBAYER
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Antioxidant responses in Phanerochaete chrysosporium exposed to Astrazone Red FBL textile dye (2012) · Evaluation of the biochemical effects of an acetamiprid-based insecticide on a non-target species, Gambusia holbrooki (2020)
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%45ELİF PAÇAL
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Sub-lethal toxicities of zinc pyrithione, copper pyrithione alone and in combination to the indicator mussel species Unio crassus Philipsson, 1788 (Bivalvia, Unionidae) (2020) · Sublethal responses of the indicator Unio species (mussel) to selected phthalate esters (2022)
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%45RUKİYE ASLAN
Shared topics: Forensic Toxicology and Drug Analysis
Overlapping papers: Çocuk ve Ergenlerde Madde Kullanımı ve Adli Toksikolojik Analizler (2023) · Development of a chemometric method in urine sample for newly designed hallucinating psychoactive substances: 5-MeO-MiPT (2023)
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%45TARIK DİNÇ
Shared topics: Environmental Toxicology and Ecotoxicology · Reproductive biology and impacts on aquatic species
Overlapping papers: Karyotype Analysis of Desmodesmus pannonicus with Scanning Electron Microscope (SEM) (2025)
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%44ADEM GÜNER
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Examination Of Some Toxicological Parameters Of Dimethylamylamine When Consumed Alone Or With Caffeine (2020) · Phytochemistry, Biological Activity and Toxicity of Botanical Dietary Supplement: KL21 (2022)
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%44AHMET TOPAL
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: The in vitro and in vivo effects of chlorpyrifos onacetylcholinesterase activity of rainbow trout brain (2016)
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%44DUYGU YEŞİM OVAT
Shared topics: Forensic Toxicology and Drug Analysis
Overlapping papers: Monitoring of Morphine in Urine After Consumption of Opium Poppy Sprouts Using Immunoassay and Liquid Chromatography Coupled with Quadrupole Exactive Orbitrap Mass Spectrometry (2026) · A 7-Year Study of Workplace Drug Testing in Two Major Cities in Türkiye (2024)
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%44EVRİM SİBEL ÖNEL
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Effect of Water Salinity on the Acute Toxicity of Mercuric Chlorideon Rainbow Trout (Oncorhynchus mykiss, Walbaum 1792) (2016) · Hazard Analysis and Human Health Risk Assessment in the Mytilus Galloprovincialis and Rapana Venosa Species in the Black Sea’s Türkiye Coastline by Multivariate Analysis (2025)
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%44TUĞBA ONGUN SEVİNDİK
Shared topics: Environmental Toxicology and Ecotoxicology
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%43ASLI ATASOY AYDIN
Shared topics: Forensic Toxicology and Drug Analysis
Overlapping papers: Toxicological Analysis of Warfarin in an Adult Developing Diffuse Alveolar Hemorrhage: A Case Report and Literature Review (2020) · New Psychoactive Substance 5-MeO-MIPT In vivo Acute Toxicity and Hystotoxicological Study (2021)
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%43AYHAN FİLAZİ
Shared topics: Pesticide Residue Analysis and Safety · Environmental Toxicology and Ecotoxicology
Overlapping papers: Avian toxicology (2025) · Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistance in Vitro (2022)
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%43BEGÜM YURDAKÖK DİKMEN
Shared topics: Environmental Toxicology and Ecotoxicology · Pesticide Residue Analysis and Safety
Overlapping papers: INVESTIGATION OF THE HEPATOTOXIC EFFECTS OF SOME HERBAL PRODUCTS BY IN VITRO METHOD (2025) · Avian toxicology (2025)
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%42BİRGÜL ÖZDEMİR
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: Anticancer potential of Origanum munzurense extract against MCF-7 breast cancer cell (2023)
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%42ELİF İPEK SATAR
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: The toxicological effects of thiamethoxam on Gammarus kischineffensis Schellenberg 1937 Crustacea Amphipoda (2015) · Fatty Acid Composition of Total Lipids in Muscle Tissues of Nine Freshwater Fish from the River Tigris Turkey (2010)
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%42FULYA BENZER
Shared topics: Environmental Toxicology and Ecotoxicology · Reproductive biology and impacts on aquatic species
Overlapping papers: Comparison of Oxidant and Antioxidant Status of Çoruh trout (Salmo coruhensis), Anatolian trout (Salmo rizeensis) and Rainbow trout (Oncorynchus mykiss) Spermatozoa (2018)
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%42HATİCE DANE
Shared topics: Environmental Toxicology and Ecotoxicology
Overlapping papers: The gonadal health status of Cyprinidae fish species collected from the river impacted by anthropogenic activities (2023) · Multi-level assessment of chronic toxicity of the insect growth regulator lufenuron in the non-target aquatic organism Daphnia magna (2026)
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