Lipid metabolism and disorders

Objectives: This study aims to assess the concentrations of angiopoietin-1, angiopoietin-2, and Tie-2, which are implicated in the pathophysiology of proliferative diabetic retinopathy (PDR), in the vitreous fluid and to evaluate the expression profiles of microRNA (miR)-145-5p, miR-542-3p, miR-5195-3p, miR-126-3p, mi…

Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening zoonotic viral disease characterized by endothelial dysfunction, coagulopathy, and systemic inflammation. Angiopoietin-like proteins (ANGPTLs) regulate vascular integrity, lipid metabolism, and inflammatory responses; however, their roles in the pathogenesis…

Aim: Familial Hypercholesterolemia (FH); a genetic disorder characterized by elevated LDL (low-density lipoprotein) cholesterol levels; is a significant risk factor for premature cardiovascular disease (CVD). Heterozygous FH (HeFH) is particularly underdiagnosed and undertreated worldwide; including in Turkey. This re…

Gastric cancer is a multifactorial disease characterized by complex interactions among transcriptional regulation, inflammation, metabolic adaptation, and angiogenesis. However, systemic molecular relationships linking these processes remain insufficiently understood. This study aimed to evaluate circulating levels of…

Background/aim: Emerging evidence suggests that dysregulated angiogenesis may contribute to the pathogenesis of Behçet's disease (BD). This study primarily aimed to investigate serum angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) levels in Turkish patients with BD and compare them with healthy controls. The seconda…

Breast and prostate cancers remain among the most prevalent epithelial malignancies worldwide, and conventional treatments often lack tumor selectivity. Aloin, an anthraquinone glycoside derived from Aloe vera, has demonstrated promising anticancer properties. This study investigated the differential cytotoxic and apo…

• MOHAMMADREZA DASTOURI

OBJECTIVES: This study aimed to evaluate serum apelin levels in obese adolescents and to investigate their association with hepatic steatosis and metabolic risk parameters. METHODS: This prospective case-control study included 75 obese adolescents and 68 age- and sex-matched healthy controls. Anthropometric measuremen…

• ERHAN SÖNMEZ

Background/Objectives: Alopecia areata is an autoimmune disorder characterized by nonscarring hair loss and systemic immune dysregulation. Hematological indices such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), systemic imm…

• GÖKHAN ŞAHİN

Background/Objectives: Alopecia areata is an autoimmune disorder characterized by nonscarring hair loss and systemic immune dysregulation. Hematological indices such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), systemic imm…

• ESRA PANCAR YÜKSEL

INTRODUCTION: Epoxyeicosatrienoic acids (EETs), synthesized by cytochrome P450 epoxygenases (mainly CYP2C9, CYP2J2, and CYP2S1), are vasoprotective lipid mediators that are rapidly degraded by soluble epoxide hydrolase (sEH). This study aimed to examine changes in EET metabolism in T2DM patients with and without DR to…

• DURMUŞ AYAN

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common condition characterized by excessive fat accumulation in the liver and is closely associated with metabolic syndrome (MetS) and insulin resistance. This study aimed to evaluate the…

• ŞEYMA DÜMÜR

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• HAVVA YAZICI
• SEMA KALKAN UÇAR