Cancer, Lipids, and Metabolism

ABSTRACT Purpose Bispecific T cell engagers (BiTEs) have recently been approved as a locoregional immunotherapy for malignant ascites. Although ascites is recognised as a lipid-rich, immunosuppressive environment, the mechanisms by which ascites, particularly its lipid components, suppress antitumour immunity remain p…

Bladder cancer is characterized by abnormal cell proliferation within the bladder lining, yet the molecular mechanisms underlying its pathogenesis remain incompletely understood. This study aimed to identify metabolic differences between bladder cancer patients and healthy controls, as well as between patients with an…

Background/Objectives: Sepsis is a life-threatening condition characterized by a dysregulated host immune response, frequently leading to multiple organ dysfunction, with the lungs being among the most severely affected organs. Oxidative stress, inflammation, apoptosis, and DNA damage play key roles in the pathogenesi…

Background Bone health plays a critical role in prostate cancer irrespective of metastatic status at diagnosis. Preptin, a peptide hormone co-secreted with insulin, exerts osteoanabolic effects and may influence tumor-related processes through insulin/IGF-related signaling pathways. However, its role in the developmen…

Breast cancer remains a major cause of cancer-related morbidity and mortality worldwide, highlighting the urgent need for novel therapeutic approaches. In this study, we aimed to investigate the combined effects of Palbociclib (PLB), a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, and Ferulic Acid (FA), a natural an…

Abstract Objective To evaluate the clinical significance of folate receptor alpha (FRα) expression in endometrial serous carcinoma. Methods We retrospectively analyzed 47 patients with histopathologically confirmed endometrial serous carcinoma who underwent hysterectomy and received systemic therapy. FRα expression wa…

PURPOSE: The prognostic value of the PSA ELIMination rate constant K (KELIM PSA) score was investigated in patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with docetaxel in combination with ADT. METHODS: This multicenter retrospective study included 105 patients diagnosed with prostate ad…

Abstract Background: Trastuzumab deruxtecan (T-DXd) has demonstrated significant clinical efficacy in metastatic breast cancer (mBC) with varying HER2 expression, including HER2-low and HER2-ultralow. Statins have been shown to increase HER2 membrane localization and stability, potentially enhancing responsiveness to…

Urologic malignancies (UMs), including prostate cancer (PCa), bladder cancer (BCa), renal cell carcinoma (RCC), and testicular germ cell tumors (TGCT), are governed by interconnected molecular pathways that regulate proliferation, angiogenesis, metabolism, invasion, immune escape, and treatment resistance. Key pathway…

Cancer progression involves intricate interactions between inflammatory signaling, programmed cell death mechanisms, and oxidative stress. Although enoxaparin is widely used for managing cancer-associated thrombosis, its direct cellular effects on tumor biology remain insufficiently characterized. This study aimed to…

Aims: Cholangiocarcinoma (CC) is a rare form of adenocarcinoma originating from the epithelial cells of the biliary tract. Chronic inflammation is known to be a risk factor for this tumor. The present study aimed to investigate whether serum levels of Maresin 1 (MaR1) (a macrophage-derived anti-inflammatory lipid medi…

Introduction: The “obesity paradox” describes the observed association between improved cancer-specific (CSS) and overall (OS) survival observed among obese (BMI ≥ 30 kg/m2) patients with RCC. Prior studies have reported lower stage/grade tumors among obese patients to explain this. This study aimed to evaluate subcut…