Electrolyte and hormonal disorders

Hypoxic–ischemic encephalopathy (HIE) is a critical neonatal condition for which therapeutic hypothermia (TH) remains the cornerstone of neuroprotective intervention. Clinical observations and prior studies note that electrolyte imbalances—particularly hyponatremia and hypokalemia—frequently emerge during TH. Therefor…

Objective: Hyponatremia is one of the most common electrolyte disorders in clinical practice and is frequently observed following thiazide use. Advanced age and female gender are implicated in the etiology of thiazide-associated hyponatremia. There has also recently been mention of a genetic disposition. This study ev…

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Background/Objectives: Electrolyte disturbances are common in patients with Acute Ischemic Stroke (AIS) and may influence clinical outcomes. However, the prognostic significance of peri-procedural electrolyte changes in patients undergoing mechanical thrombectomy remains insufficiently investigated. This study aimed t…

Background: Serum osmolarity, reflecting fluid and electrolyte balance, may serve as a prognostic marker in critically ill patients, but its role in COVID-19 is not well established. This study evaluated the association between admission serum osmolarity and in-hospital mortality in critically ill COVID-19 patients. M…

Abstract Objective Chronic kidney disease (CKD) is characterized by progressive decline in glomerular filtration rate (GFR) and is associated with activation of neurohormonal pathways, including the arginine vasopressin system. Copeptin, the C-terminal fragment of pre-pro-vasopressin, has emerged as a stable surrogate…

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Amaç: Çocuk acil servisine başvuran ve hiponatremi saptanan hastaların demografik, klinik ve laboratuvar özelliklerinin değerlendirilerek hastane yatışı ve orta-ağır hiponatremi ile ilişkili faktörlerin belirlenmesi amaçlandı. Gereç ve Yöntem: Bu retrospektif çalışmaya, 1 Haziran 2025 ile 31 Aralık 2025 tarihleri aras…

BACKGROUND: Neonatal hypernatremic dehydration (NHD) is a dangerous disease that can lead to hospitalization of the infant, serious complications, and death. Despite the significant advantages of breast milk for both the mother and the baby, some neonates who are exclusively breastfed experience malnutrition in the fi…

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Purpose: Hypernatremia is a common electrolyte disorder in pediatric intensive care units (PICU) and is associated with considerable morbidity and mortality. We aimed to evaluate underlying etiologies, clinical characteristics, and factors associated with outcomes in critically ill children with hypernatremia, while a…

Objective: Reset osmostat (RO) is an under-recognized disorder of osmoregulation characterized by a downward resetting of the plasma osmolality threshold for arginine vasopressin release. Affected individuals develop chronic, typically mild and stable hypotonic hyponatremia while preserving the ability to dilute urine…