Connexins and lens biology

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Contrast-associated acute kidney injury (CA-AKI) remains a clinically relevant complication of iodinated contrast exposure. Carnosic acid possesses antioxidant and anti-inflammatory properties, but its effects on renal biochemical injury, tubular damage, and inducible nitric oxide synthase (iNOS) immunoreactivity in C…

Background: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of intermittent hypoxia and systemic inflammation. Pannexin-1 (Panx1) is a transmembrane channel involved in ATP release and purinergic signaling and has been implicated in hypoxia-related inflamm…

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Objectives: The purpose of this study was to evaluate the effects of adrenergic receptor antagonists on pupillary function in patients with benign prostatic hyperplasia (BPH) and to compare the pupillometric alterations between the A-selective blocker tamsulosin and the non-subtype-selective blocker doxazosin. Methods…

BACKGROUND: Cerebrotendinous xanthomatosis (CTX) is a rare yet treatable neurometabolic disorder caused by pathogenic variants in the CYP27A1 gene. Juvenile-onset cataracts may precede systemic signs, allowing for early diagnosis. This study evaluated the prevalence of CYP27A1 variants in patients with bilateral juven…

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This study investigated associations between serum and cerebrospinal fluid (CSF) estradiol (E2) and progesterone (P4) levels and body temperature regulation in thirty clinically healthy bitches. Right and left corneal temperatures (RCT, LCT), perianal and perivulvar temperatures were measured by infrared thermography,…

Abstract Backgrounds: We aimed to compare serum complement C3, C3a, and C4 levels between cataract patients with and without pseudoexfoliation syndrome, and to compare these groups with the control group. Methods: There were three different groups in the study. The total of 150 patients, 50 in each group, were include…

To report a case of long-standing occupational ocular argyrosis with histopathological confirmation during cataract surgery. A 57-year-old male silver worker with a 16-year history of ocular argyrosis and progressive visual deterioration underwent comprehensive ophthalmological examination and phacoemulsification with…

CLINICAL RELEVANCE: Quantitative evaluation of lens transparency may aid the clinical assessment of normal and abnormal lenticular changes during childhood. BACKGROUND: Scheimpflug imaging enables objective measurement of crystalline lens light backscatter. While age-related increases in lens densitometry are well doc…