OpenAlex topic
Neuroinflammation and Neurodegeneration Mechanisms
This page lists works and academicians tagged with an OpenAlex topic. It is not a YÖKSİS primary or secondary field.
OpenAlex 1,527 works 51 author topics
Works
1,058 works
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Parkinson's disease (PD) imposes a growing socioeconomic burden due to its increasing prevalence and lack of a cure. Existing treatment options primarily manage motor and nonmotor symptoms but do not halt or slow disease progression, underscoring the urgent need for more effective and preventative strategies. Growing…
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Glioblastoma (GBM) remains one of the most lethal primary brain tumors despite maximal surgical resection, radiotherapy, and temozolomide. Immune checkpoint inhibitors have failed to demonstrate durable benefit in three large phase III trials (CheckMate 143, 498, and 548), underscoring profound, multilayered immune re…
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Multiple Sclerosis (MS) is a chronic immune-mediated demyelinating disorder of the central nervous system and represents a leading cause of non-traumatic neurological disability in young adults. Its pathophysiology is characterized by a complex interplay between inflammatory mechanisms and neurodegenerative processes,…
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Multiple Sclerosis (MS) is a chronic immune-mediated demyelinating disorder of the central nervous system and represents a leading cause of non-traumatic neurological disability in young adults. Its pathophysiology is characterized by a complex interplay between inflammatory mechanisms and neurodegenerative processes,…
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ABSTRACT This study aims to investigate expanded hematological data in multiple sclerosis (MS) and evaluate their association with disease severity. A total of 190 patients participated in the study. For this purpose, expanded hemocytometry data were compared between 120 patients diagnosed with MS and 70 healthy contr…
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Multiple sclerosis (MS) is a neuroinflammatory disease associated with involving metabolic disruptions. Although amino acid metabolism is linked to MS pathophysiology, its role remains unclear. This study investigates alterations in amino acid profiles to identify potential biomarkers for MS. Plasma and cerebrospinal…
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Oxidative stress and apoptosis contribute to seizure-associated neuronal injury, but the effects of ML-171, a pharmacological NOX-1 inhibitor, on PTZ-associated oxidative and apoptotic injury remain insufficiently defined. This study evaluated the effects of the NOX-1 inhibitor ML-171 in pentylenetetrazole (PTZ)-induc…
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Traumatic brain injury (TBI) is a condition characterized by high morbidity and mortality. This study investigated the therapeutic effects of ketamine on TBI through electrophysiological and immunohistochemical methods in a model of 30 rats divided into five equal groups. Following trauma, ketamine, mannitol, and hype…
Academicians
51 academicians
- ERTUĞRUL KILIÇ 41 author topics
- ÜLKAN ÇELİK 21 author topics
- MUSTAFA ÇAĞLAR BEKER 11 author topics
- AYŞE KARSON 9 author topics
- KEMAL UĞUR TÜFEKCİ 9 author topics
- BURHANETTİN ÇİĞDEM 7 author topics
- GÜL İPEK GÜNDOĞAN 7 author topics
- İZZETTİN HATİP 7 author topics
- MEHTAP SAVRAN 7 author topics
- ASLI BOLAYIR 6 author topics
- BÜLENT AHISHALI 6 author topics
- GÜVEN AKÇAY 6 author topics