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OpenAlex topic

Ion Channels and Receptors

This page lists works and academicians tagged with an OpenAlex topic. It is not a YÖKSİS primary or secondary field.

OpenAlex 896 works 36 author topics

Works

896 works

  1. Transient Receptor Potential Channel Signaling in Hypertension: Mechanisms, Translation, and Therapeutic Targeting 2026

    Arterial hypertension (HT) is a major risk factor in the pathogenesis of cardiovascular diseases and has a high prevalence. The pathogenesis of primary HT, which accounts for the majority of HT cases, has not been fully elucidated; therefore, effective treatment targets remain an important area of research. Transient…

  2. Protective effects of Pelargonium sidoides against oxidative stress and inflammation in experimental mesenteric ischemia-reperfusion injury 2026

    No abstract yet.

  3. Dual TRPM2–PLA₂ Blockade Induces Redox Reprogramming and Selective Apoptosis in Prostate Cancer Cells 2026

    No abstract yet.

  4. Luteolin reduces sciatic nerve damage and modulates TRPV1 and TRPM2 expression in diabetic rats 2026

    BACKGROUND: Hyperglycemia drives peripheral nerve damage through oxidative stress, inflammation, and apoptosis, yet the role of redox-sensitive ion channels in linking these processes remains poorly understood. OBJECTIVE: This study investigates the neuroprotective effects of luteolin (LUT) on streptozotocin (STZ)-ind…

  5. Anti-Neuropathic Pain Activity of Epigallocatechin Gallate in an Experimental Diabetic Neuropathic Pain Via Inhibition of TRPV1 and iNOS 2026

    Introduction: Diabetic neuropathic pain (DNP) is an important complication of diabetes.EGCG is known to have antioxidant, antiinflammatory, and antidiabetic effects.TRPV1 channel and iNOS are pain-related pathways.In this experimental DNP study, we examined the effects of EGCG on the sciatic nerve, focusing specifical…

  6. Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis via inhibition of TRPA1 channel in retinal pigment epithelial cells 2026

    AIM: To investigate the modulator action of resveratrol (RSV) through the suppression of transient receptor potential ankyrin 1 (TRPA1) on the hypoxia (HPO)-caused oxidative degeneration and apoptosis in human retinal pigment epithelial cells (ARPE19). METHODS: The control (CNT), RSV (50 µmol/L for 24h), HPO (200 µmol…

  7. Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells 2026

    No abstract yet.

  8. TRPM2 channel increases cell viability of triple negative breast cancer cells following chemotherapy through altered mitochondrial calcium homeostasis 2026

    Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen receptor, progesterone receptor, and HER2 overexpression. Its poor prognosis arises from a combination of factors, including the lack of targeted therapeutic options, intrinsic tumor aggressiveness, and high recurren…

  9. Solanum nigrum L. Extract Decreases Parkinsonism‐Induced Oxidative Neurodegeneration Through the Inhibition of TRPM2 Channel 2026

    Parkinson’s disease is caused by the 1‐methyl‐4‐phenylpyridinium (MPP)‐induced stimulation of the TRPM2 channel and the generation of free reactive oxygen species (ROS). The stimulation in SH‐SY5Y neuronal cells may be suppressed by the antioxidant Solanum nigrum L. (SNL) extract and TRPM2 antagonist (N‐(p‐amylcinnamo…

  10. Cisplatin Kills Ovarian Cancer Cells by Causing Mitochondrial Oxidative Stress and Death Through the TRPV1 Channel Stimulation: The Role of Eicosapentaenoic Acid 2026

    Introduction: Cisplatin (Cisp) causes excessive Ca2+ and Zn2+ influxes mediated by TRPV1 channel stimulation and produces a high concentration of mitochondrial (mROS) and cytosolic (cROS) free reactive oxygen radicals. In clinical trials, it can be used in combi-nation with other adjuvant medicinal agents to enhance t…

  11. Selenium protects granulosa cells from 3-nitropropionic acid-induced oxidative toxicity by regulating TRPM2-induced cell death 2026

    No abstract yet.

  12. Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity 2026

    No abstract yet.

Academicians

36 academicians