Antiplatelet Therapy and Cardiovascular Diseases

Opioid analgesics, particularly morphine and fentanyl, remain used in acute myocardial infarction (AMI) to relieve severe ischaemic pain and attenuate pain-driven sympathetic activation. Their role has become more complex in contemporary reperfusion care because μ-opioid receptor activation in the enteric nervous syst…

Objective: Coronary artery bypass grafting (CABG) remains a widely performed surgical intervention for coronary artery disease. Despite advances in perioperative care and preoperative risk stratification, postoperative complications and mortality continue to pose significant clinical challenges. This study aimed to in…

Background and Objectives: Obesity is a major global public health problem associated with numerous complications. Likewise, the use of antiplatelet and anticoagulant agents has increased with population aging and the growing burden of cardiovascular diseases. This study aimed to evaluate the effects of obesity and an…

Aim: Early risk stratification in the emergency department (ED) is critical for patients presenting with ST-elevation myocardial infarction (STEMI). This study aimed to evaluate the prognostic performance of commonly used clinical risk scores (TREWS, REMS, TIMI, and C-ACS) and readily available laboratory ratios, incl…

Background/Objectives: Cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP3A4) play a key role in interindividual variability in cardiovascular drug metabolism. This study aimed to describe metabolizer phenotype distributions in a Turkish emergency cardiac cohort and across diagnostic categories. Methods: This retrospective…

BACKGROUND AND AIMS: Lower gastrointestinal bleeding is a prevalent issue in the general population, particularly among older adults. Identifying risk factors is essential for improving healthcare outcomes. This study seeks to evaluate the clinical outcomes related to the use of medications recognized as risk factors,…

Cancer progression involves intricate interactions between inflammatory signaling, programmed cell death mechanisms, and oxidative stress. Although enoxaparin is widely used for managing cancer-associated thrombosis, its direct cellular effects on tumor biology remain insufficiently characterized. This study aimed to…

Acute ischemic stroke is one of the leading causes of morbidity and mortality in adults. Although intravenous thrombolytic therapy (IVTT) can improve neurological recovery in appropriate patients, the treatment response shows variability among individuals. Although the NIHSS score is widely used to monitor clinical re…

INTRODUCTION: Postoperative bleeding increases morbidity and mortality. We aimed to review the scoring systems used to predict massive bleeding after isolated coronary artery bypass grafting in diabetic patients and determine the parameters of the new scoring system - the Optimum Risk Score for Bleeding (ORS). METHODS…

Acetylsalicylic acid (ASA, aspirin), derived from salicylic acid in willow bark, is known for its analgesic, anti-inflammatory, and antiplatelet properties. Beyond cardiovascular protection, increasing evidence suggests that ASA may reduce the risk of various cancers, including colorectal and prostate cancer. In this…

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