Bipolar Disorder and Treatment

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• METİN DEMİREL

Introduction: Bipolar disorder is a complex psychiatric condition marked by recurrent episodes of mania and depression. Despite its prevalence, the underlying pathophysiology remains poorly understood, and there is still a lack of objective biomarkers for diagnosis. Metabolomics is a promising approach for exploring b…

• FATMANUR KÖKTAŞOĞLU

No abstract yet.

• FATMANUR KÖKTAŞOĞLU

INTRODUCTION: This cross-sectional descriptive study aims to examine the relationship between perceived social support, treatment adherence and recovery in individuals diagnosed with bipolar disorder. The impact of social support elements, especially family, friend and special person support, on the treatment adherenc…

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Background The study investigated whether manic/hypomanic symptoms mediate the link between impulsivity dimensions and ADHD severity. Methods Initially, 175 adolescents aged 12–18 years were recruited; following three exclusions due to incomplete records, the final sample comprised 62 adolescents with ADHD and 110 con…

BACKGROUND: Clozapine is the most effective treatment for treatment-resistant schizophrenia, yet substantial interindividual variability in serum concentrations complicates dose optimization and therapeutic drug monitoring. While factors such as smoking and inflammation are known to influence clozapine metabolism, a s…

Background: Recent evidence has suggested that low-grade systemic inflammation may contribute to the clinical expression of mood disorders, yet findings have differed considerably across studies. The present study compared several complete blood-count (CBC)-derived inflammatory indices among inpatients with bipolar di…

Subclinical paranoia and social anxiety frequently co-occur in non-clinical populations, yet the cognitive mechanisms underlying their association remain unclear. This study examined whether social anxiety severity is associated with paranoid tendencies among university students and whether cognitive biases account fo…

RATIONALE: Systemic inflammation is increasingly recognized as a key component of the pathophysiology and neuroprogression of bipolar disorder (BD). Novel hematologic indices, including the NLR, PLR, SII, SIRI, and PIV, provide accessible measures of the inflammatory burden. However, the impact of mood stabilizers on…

BACKGROUND: Bipolar disorder (BD) is associated with abnormalities in large-scale white matter connectivity, with the corpus callosum (CC) being one of the most consistently implicated structures. However, the relationship between proportional CC measures and clinical variables in BD has not yet been clearly establish…

Objective: To examine the associations between somatic symptoms, emotional features (alexithymia), and cognitive functions (specifically, premorbid intelligence and verbal fluency) among patients attending a psychiatric outpatient clinic. While previous studies have frequently linked somatization with emotional dysreg…