Ion Transport and Channel Regulation

Copper (Cu) is a cofactor for most enzymes and an essential trace element. However, elevated levels of Cu exposure cause toxic effects in various tissues. Aquaporins (AQP) are integral membrane proteins that play a key role in fluid transport, particularly in kidney tissues. In our study, we aimed to evaluate the expr…

Hypoxic–ischemic encephalopathy (HIE) is a critical neonatal condition for which therapeutic hypothermia (TH) remains the cornerstone of neuroprotective intervention. Clinical observations and prior studies note that electrolyte imbalances—particularly hyponatremia and hypokalemia—frequently emerge during TH. Therefor…

Objective: Hyponatremia is one of the most common electrolyte disorders in clinical practice and is frequently observed following thiazide use. Advanced age and female gender are implicated in the etiology of thiazide-associated hyponatremia. There has also recently been mention of a genetic disposition. This study ev…

No abstract yet.

No abstract yet.

Abstract Objective Chronic kidney disease (CKD) is characterized by progressive decline in glomerular filtration rate (GFR) and is associated with activation of neurohormonal pathways, including the arginine vasopressin system. Copeptin, the C-terminal fragment of pre-pro-vasopressin, has emerged as a stable surrogate…

No abstract yet.

No abstract yet.

Objective: Reset osmostat (RO) is an under-recognized disorder of osmoregulation characterized by a downward resetting of the plasma osmolality threshold for arginine vasopressin release. Affected individuals develop chronic, typically mild and stable hypotonic hyponatremia while preserving the ability to dilute urine…

Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that catalyze the reversible conversion of carbon dioxide and water into bicarbonate and protons, contributing to acid-base balance, pH regulation, and ion transport. Among human cytosolic isoforms, carbonic anhydrase I (CA I) and carbonic anhydrase II (CA I…

No abstract yet.

Türkiye is among the unique and important countries in the world in terms of plant genetic resources and diversity. Zirmek (Ruscus colchicus) plant is a species from the Asparagaceae family. It is aimed to investigate the total phenolic content (TPC), antioxidant 2,2'-azinobis-(3- 3-ethylbenzothiazoline-6-sulfonic aci…