Inflammatory mediators and NSAID effects

This study evaluated the effects of preemptively administered nonsteroidal anti-inflammatory drugs (NSAIDs) on wound healing, inflammation, and oxidative stress in rats. 24 male Sprague-Dawley rats were assigned to four groups: no NSAID (Control), preemptive NSAID (Group 1), postoperative NSAID (Group 2), and pre- and…

• EMİNE RÜMEYSA HEKİMOĞLU

Cyclooxygenase-2 (COX-2) is an inducible enzyme that plays a central role in inflammation and has long been recognized as a compelling target for anti-inflammatory therapy. The introduction of selective COX-2 inhibitors marked a major advance, offering improved gastrointestinal safety over traditional nonsteroidal ant…

The present study aimed to comparatively evaluate the antinociceptive and anti-inflammatory effects of oleic acid (OA) and linoleic acid (LA), administered individually and in combination, and to investigate their impact on serum pro-inflammatory cytokines in an experimental animal model. A total of 96 rats were orall…

Background/Aims: Proton pump inhibitors have been reported to exert anti-inflammatory and antioxidant effects independent of gastric acid suppression; however, their role in inflammatory bowel disease remains unclear. The current study investigated whether rabeprazole modulates oxidative stress-related and inflammator…

The indole scaffold is common in natural products and bioactive compounds, including anti-cancer and anti-inflammatory medicines. In this work, a series of indole-acrylamide derivatives was synthesized, and their antiproliferative and anti-inflammatory effects were evaluated on COX enzymes and against a panel of cance…

Introduction Artemisia kurramense has been used for gastrointestinal and inflammatory conditions, but no attempt has been made to explore the possible computational molecular mechanism against Helicobacter pylori -associated gastric pathogenesis. This study aimed to develop a computational hypothesis of the therapeuti…

Acetylsalicylic acid (ASA, aspirin), derived from salicylic acid in willow bark, is known for its analgesic, anti-inflammatory, and antiplatelet properties. Beyond cardiovascular protection, increasing evidence suggests that ASA may reduce the risk of various cancers, including colorectal and prostate cancer. In this…

Abstract In this study, a new series of nimesulide-derived ureas (3a–j) was designed and synthesized to investigate structural modifications of nimesulide and to evaluate their biological activity. The compounds were obtained in high yields (68–88%) under organotin-catalyzed conditions, and their structures were unequ…

Background: Acute renal colic is a common urological emergency characterized by substantial interindividual variability in analgesic response. Pharmacogenetic variation in OPRM1, COMT, and ABCB1 may contribute to differences in opioid efficacy and pain control. This study primarily evaluated the associations of OPRM1…

Acute and chronic inflammation are known to contribute to the pathogenesis of various diseases, including cardiovascular disorders, Parkinson's, Alzheimer's, diabetes, and cancer. Classical nonsteroidal anti‐inflammatory drugs reduce inflammation primarily by suppressing the cyclooxygenase (COX) pathway. COX enzymes f…

Pharmacologic management of acute musculoskeletal (MSK) pain with muscle spasm frequently involves the combination of nonsteroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs). While the combination of cyclobenzaprine and various NSAIDs has been studied, the co-prescribing of cyclobenzaprine w…

OBJECTIVE: Our aim in this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values of diclofenac sodium, which is a non-steroidal anti-inflammatory analgesic, after sciatic nerve injury, to examine the histopathological changes in the sciatic nerv…