Genetics, Aging, and Longevity in Model Organisms

Regular exercise is a cornerstone of healthy longevity. Exercise has numerous effects on aging mechanisms, including telomere integrity, mitochondrial function, genomic stability, and inflammatory processes. The literature contains studies investigating the effects of various types of exercise on lifespan and quality…

Inflammatory rheumatic diseases (IRDs) are increasingly recognized as disorders of accelerated biological aging, characterized by chronic inflammation, immunosenescence, cellular senescence, and progressive loss of physiological resilience. These processes contribute to frailty, multimorbidity, functional decline, and…

Alternate-day fasting (ADF) may exert age-related anti-inflammatory effects by modulating key metabolic and immune pathways. This study aimed to investigate the sex-specific effects of ADF on inflammation in middle-aged male and female rats and focused on the Toll-like receptor 4 (TLR4) and leptin signaling pathways.…

Menopause is a complex biological condition associated with progressive estrogen depletion and increased susceptibility to several age-associated disorders. During this process, several biological mechanisms, such as mitochondrial dysfunction, oxidative stress, chronic inflammation, genomic instability, and immunosene…

PURPOSE. Sarcopenia, the age-related loss of skeletal muscle mass, strength and physical performance, is a leading cause of disability, falls and loss of independence in older adults. Drosophila melanogaster is one of the most widely used invertebrate models of muscle ageing, offering a short lifespan, powerful geneti…

Collective animal behaviors arise from a complex interplay between internal physiological states and external environmental cues. In Caenorhabditis elegans , favorable conditions promote dispersal, while stressors like food scarcity trigger aggregation. Here, we describe a distinct self-organized swarming behavior, wh…

This project is a systematic review, meta-analysis, and meta-regression designed to comprehensively evaluate the effects of strict water-only fasting on body composition and anthropometric outcomes in adults. Water-only fasting, defined as complete abstinence from caloric intake with unrestricted water consumption, ha…

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Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is characterized by a range of molecular and cellular mechanisms, including genomic instability, telomere a…

Introduction Aging is characterized by declining NAD + levels, mitochondrial dysfunction and disruption of redox homeostasis. Multi-component formulations targeting interconnected hallmarks of aging have emerged as potential geroprotective strategies. Methods We evaluated the molecular and functional effects of Elixea…

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