Hematopoietic Stem Cell Transplantation

The immature reticulocyte fraction (IRF) reflects early erythropoietic activity and is used to monitor hematopoietic function clinically. However, the physiological behavior of the IRF in healthy individuals of different ages has not been thoroughly investigated. This study evaluates age-related variations in the IRF…

• MUHİTTİN ABDULKADİR SERDAR

Introduction & Objective: Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), with limited treatment options for steroid-resistant cases. Ruxolitinib, a JAK1/2 inhibitor, has shown promise in treating steroid-resistant acute (aGVHD), chronic (cGVH…

Relapse of acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation (allo-HCT) remains a life-threatening complication and is influenced by the underlying biology of the AML and possibly by genetic alterations. In this retrospective multicenter study, we evaluated mutational dynamics of AML…

Objective: STR-PCR is the gold standard for monitoring chimerism following haematopoietic stem cell transplantation. However, it fails to detect mixed and microchimerism due to a sensitivity limit of 1%, as well as technical issues such as stutter peaks and allelic imbalance. Despite these limitations, this study aims…

Infectious complications remain a leading cause of mortality after hematopoietic stem cell transplantation (HSCT). We aimed to describe post-HSCT infections and their impact on survival in a center from a region with high antimicrobial resistance. We included 522 patients with hematological malignancies undergoing HSC…

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Objective: Plasma cell contamination in freshly collected autografts has been rigorously investigated as a marker to identify patients at a high risk of progression after autologous stem cell transplantation (ASCT), with conflicting results. The association between the plasma cell content in thawed autografts and clin…

INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) provides definitive treatment for many inborn errors of immunity (IEI). Although most children achieve full immune reconstitution, long-term psychosocial and quality-of-life outcomes in medically stable survivors remain insufficiently understood. METHODS: Ch…

Background/Objectives: Cytomegalovirus (CMV) reactivation is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Letermovir is used to prevent infections, but it is not available in many countries. Ganciclovir and valganciclovir carry a risk of bone marrow s…