Cancer Cells and Metastasis

For decades, peritoneal metastases (PM) have been regarded as a terminal manifestation of advanced malignancies and managed primarily with palliative intent because of limited sensitivity to systemic therapies. Accumulating clinical, molecular, and immunological evidence now supports the view that PM is not merely an…

• UĞUR TOPAL

Metastasis is a complex, multistep process that underlies the majority of cancer-related deaths and is increasingly recognized as a consequence of dynamic epigenetic reprogramming rather than solely genetic alterations. Epigenetic mechanisms enable stable yet reversible changes in gene expression that drive cellular p…

• SEVAL TURNA

Breast cancer is among the leading causes of cancer mortality worldwide, with aging as a major risk factor. Caloric restriction (CR) is a well-established non-pharmaceutical intervention that extends healthspan and delays tumorigenesis, yet the systemic molecular mechanisms remain elusive. Both chronic and intermitten…

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Abstract We and other researchers have recently demonstrated in vitro that chemoresistant and stem-like triple-negative breast cancer cells preferentially obtain energy through mitochondrial oxidative phosphorylation (OXPHOS) compared to their chemosensitive counterparts, which undergo glycolysis. Proteomic profiling…

Circulating tumor cells (CTCs) are important biomarkers for metastatic progression, but their label-free enrichment from blood remains challenging because of their rarity, heterogeneity, and partial size overlap with hematologic cells. In this study, we present a serpentine inertial microfluidic platform for the label…

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell lung cancer (NSCLC) accounting for the majority of cases. Standard tissue biopsies are invasive and unsuitable for repeated monitoring. Liquid biopsy technologies, particularly circulating tumor cell (CTC) analysis, offer a min…

Abstract Cancer-associated fibroblasts (CAFs) are a central component of the tumor microenvironment that facilitate a supportive niche for cancer progression and metastasis. Experimental evidence suggests that CAFs can facilitate estrogen-independent tumor growth, thereby reducing the efficacy of anti-hormonal therapi…

Adaptation of metastatic cells to their host tissue determines the pathogenicity of cancer. Yet, it remains elusive to what extent the host environment drives gene expression programs in metastatic cells. We present a new concept to identify adaptive mechanisms that enable metastases to establish themselves in a novel…