DNA Repair Mechanisms

DNA repair mechanisms have been a remarkable subject in algae, as in every living organism. Continuous exposure to mutagens has led to the evolution of protection mechanisms in primary producer algae of aquatic ecosystems and various pathways have developed in multiple algae. These pathways are direct and indirect. Un…

Abstract The three-dimensional (3D) genome architecture is highly elastic, adapting to nuclear processes such as transcription and the DNA damage response 1,2 . Nucleotide excision repair (NER) acts within this chromatin context to detect and repair mutagenic lesions induced by ultraviolet (UV) irradiation 3 . UV irra…

Drosophila melanogaster has been extensively used as a model system to study ionizing radiation and chemical-induced mutagenesis, double-strand break repair, and recombination. However, there are only limited studies on nucleotide excision repair in this important model organism. An early study reported that Drosophil…

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Severe Acute Respiratory Syndrome Coronavirus-2, which causes Coronavirus 2019, has resulted in the deaths of more than 7 million people. The helicase, encoded by non-structural protein-13 in the virus genome, plays a critical role in the virus's life cycle and is at the heart of treatment approaches. The study reveal…

Objective: Plants rely on nucleotide excision repair to eliminate UV-induced pyrimidine dimers, which disrupt transcription and replication, thereby supporting growth and development under UV stress. In this process, endonucleases, the XPF–ERCC1 complex, and XPG in mammals make dual incisions around the damage site. I…

BACKGROUND: Ataxia-telangiectasia (AT) is a rare disorder leading to multisystem involvement due to impaired DNA repair. Recent advances in targeted therapies highlight the importance of early diagnosis. This study aimed to evaluate clinical, radiological, and genetic variability in patients with AT and examine genoty…

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Abstract Rothmund–Thomson syndrome is a rare autosomal recessive genodermatosis characterized by poikiloderma, growth retardation, juvenile cataracts, congenital anomalies, and skeletal defects. Rothmund–Thomson syndrome type 2 is caused by biallelic mutations in the RECQL4 gene, leading to DNA repair deficiency and c…

• AHMET CEVDET CEYLAN

BACKGROUND: Xeroderma pigmentosum (XP) is a rare DNA damage repair disorder. Seven distinct complementation groups and an XP variant form have been identified; however, limited literature exists on the genotype-phenotype correlation in XP. OBJECTIVES: To explore the manifestations of XP variants in patients from Türki…

• ŞULE ALTINER
• YILDIZ GÜRSEL ÜRÜN