SARS-CoV-2 and COVID-19 Research

Background: Households represent a major setting for SARS-CoV-2 transmission due to prolonged close contact and shared living environments. Although household transmission has been widely investigated, studies focusing on households including children and incorporating long-term follow-up data remain limited. Methods:…

Objective: To evaluate the association between second-dose vaccination status, clinical characteristics, treatment modalities, and laboratory parameters with intensive care unit (ICU) mortality among patients with COVID-19 who had received at least one dose of vaccination.Methods: This single-center retrospective coho…

Background and Aims: Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well-known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa. However, it has caused rare outbreaks in isolat…

Background This study aimed to assess culture positivity rates and the microbiological profile of intensive care unit (ICU)-acquired superinfections in patients with severe COVID-19 pneumonia treated with pulse-dose methylprednisolone, with or without adjunctive tocilizumab.Research design and methods A total of 443 a…

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The renin-angiotensin system (RAS) regulates inflammation, tissue homeostasis, and barrier integrity in lung and colon epithelial cells. Beyond classical pathways, non-canonical components including angiotensin-converting enzyme 2 (ACE2), epidermal growth factor receptor (EGFR), insulin-like growth factor 2 receptor (…

Background: We tested whether COVID-19 vaccination affects the risk of preeclampsia (PE) given the well-documented association between COVID-19 and PE, and their overlapping risk factors and pathophysiological pathways. Methods: We analysed individual level data from pregnant women prospectively enrolled from 18 count…

Purpose: The COVID-19 pandemic has had a significant impact on solid organ transplantation (SOT), creating challenges in clinical management and contributing to substantial morbidity and mortality. By presenting our experience with immunosuppressive therapy management during COVID-19 infection in liver and kidney tran…

Introduction/Objective: As SARS-CoV-2 continues to evolve, researchers need computational tools that support interactive exploration of mutation probabilities and interpretation of modelderived signals in genomic surveillance. This study presents CovMutEx (COVID-19 Mutation Explorer), an open-source, web-based softwar…

BACKGROUND: SARS-CoV-2 enters host cells primarily through angiotensin-converting enzyme 2 (ACE2) and requires proteolytic activation by transmembrane serine protease 2 (TMPRSS2) or cysteine proteases cathepsin B and L (CTSB/L). The expression levels of these host factors may influence viral entry, tissue tropism, and…

Background: This study aimed to evaluate the vaccination rates, knowledge levels, and the influence of demographic, socioeconomic, and health perception factors on the uptake of influenza, pneumococcal, hepatitis B, and COVID-19 vaccines among patients undergoing hemodialysis (HD). Methods: Between February and March…

This study aimed to assess the humoral immune response following administration of a BNT162b2 mRNA COVID-19 booster dose and to evaluate its association with the development of SARS-CoV-2 infection after vaccination. Between July 2021 and February 2022, serum samples were collected from 313 individuals 28 days after r…