Alzheimer's disease research and treatments

hnRNPA1 proteininin düşük komplekslik (LC) bölgesi, hem normal hücresel süreçlerde hem de nörodejeneratif hastalıkların patogenezinde kritik bir role sahiptir. Bu bölge içerisinde yer alan PY-NLS motifi, nükleer taşınımda karyoforin-β2 ile yüksek afiniteli etkileşimler kurmasının yanı sıra amiloid fibril çekirdeğinin…

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INTRODUCTION/OBJECTIVE: Down Syndrome (DS) is a genetic disorder caused by trisomy of human chromosome 21 and represents the most common genetic cause of intellectual disability. It is also associated with an increased risk of developing Alzheimer's Disease (AD). Although various pharmacological treatments have been s…

Introduction: Aluminium is a ubiquitous neurotoxin associated with Alzheimer’s disease pathology. In this study, we aimed to investigate the effects of subchronic oral aluminium administration on spatial memory and neuroinflammatory markers, as well as the potential impact of concurrent metformin administration on the…

Alzheimer Hastalığı (AH), patolojik olarak nöronal kayıp, amiloid-beta (Aβ) plaklarının ve hiperfosforile tau nörofibriler yumaklarının (NFY'ler) birikimiyle karakterize, ilerleyici bir nörodejeneratif bozukluktur. Mevcut farmakolojik yönetim, bilişsel işlevi artıran veya eksitotoksisiteyi azaltan asetilkolinesteraz i…

Introduction/ Objective: MRI-based Alzheimer’s staging is often modeled as separate tasks, although clinical assessment progresses from screening to more refined staging. This study developed a continual-learning framework for retaining earlier diagnostic knowledge. Methods: A nested multi-head framework was implement…

Background/Objectives: Circulating trace-element differences have been reported in neurodegenerative disorders, but data in multiple system atrophy (MSA) are scarce. We compared eleven trace elements and two operationally defined exploratory composite indices between patients with MSA and controls. Methods: This case–…

Aim: This study aimed to investigate the relationship between lipid profile parameters (including the atherogenic index of plasma (AIP)) and cognitive function in patients diagnosed with Alzheimer’s disease (AD), based on Mini-Mental State Examination (MMSE) scores measured at the same visit and after a two-year follo…

The global prevalence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing significantly in an age-dependent manner. Growing evidence supports the conceptualization of AD as 'type 3 diabetes,' a term proposed to describe a metabolic disease primarily driven by impaired insulin signalling and i…

Objective: In this study we aimed to investigate the effects of curcumin and resveratrol antioxidant enzymes in β-amyloid (Aβ)-induced in vitro Alzheimer's Disease (AD) cell model.Materials and Methods: Three groups were created in this study; The control group consisted of U87 cells, the Aβ group which was the in vit…

Introduction: Alzheimer's disease (AD) is a prevalent and irreversible neurodegenerative condition, ranking as the seventh leading cause of global mortality. This complex ailment encompasses various clinical and imaging-based classifications. Nonetheless, the use of pedigree analysis offers an additional layer of insi…

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