Parkinson's Disease Mechanisms and Treatments

Parkinson's disease (PD) imposes a growing socioeconomic burden due to its increasing prevalence and lack of a cure. Existing treatment options primarily manage motor and nonmotor symptoms but do not halt or slow disease progression, underscoring the urgent need for more effective and preventative strategies. Growing…

• BÜŞRA AKTAŞ MANSUROĞLU

hnRNPA1 proteininin düşük komplekslik (LC) bölgesi, hem normal hücresel süreçlerde hem de nörodejeneratif hastalıkların patogenezinde kritik bir role sahiptir. Bu bölge içerisinde yer alan PY-NLS motifi, nükleer taşınımda karyoforin-β2 ile yüksek afiniteli etkileşimler kurmasının yanı sıra amiloid fibril çekirdeğinin…

Abstract Parkinson’s disease is characterized by a detrimental effect on numerous motor abilities and gait. It was aimed to investigate the position of arm ergometer exercises in rehabilitation of Parkinson’s Disease and their contribution in severity of the disease and ambulation. 33 patients completed the prospectiv…

Objective: Adult attention-deficit/hyperactivity disorder (ADHD) remains a clinically heterogeneous condition.Oxidative stress has been implicated, but biomarkers with clinical utility remain limited.NADPH oxidase (NOX) isoforms-particularly NOX2 and NOX4-generate reactive oxygen species and may drive lipid peroxidati…

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Parkinson’s disease is caused by the 1‐methyl‐4‐phenylpyridinium (MPP)‐induced stimulation of the TRPM2 channel and the generation of free reactive oxygen species (ROS). The stimulation in SH‐SY5Y neuronal cells may be suppressed by the antioxidant Solanum nigrum L. (SNL) extract and TRPM2 antagonist (N‐(p‐amylcinnamo…

LRRK1 protein is sole paralog of LRRK2 protein, which plays a role in autosomal dominant Parkinson’s disease inheritance in humans. Both proteins share similar domain organization characteristics. Like LRRK2, LRRK1 also possesses kinase and GTPase activities. However, role of LRRK1 in pathogenesis of Parkinson’s disea…

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Background: Restless legs syndrome (RLS) is traditionally considered a sensorimotor disorder, but increasing evidence suggests that it may also involve brain systems related to emotional and cognitive functions. In this exploratory study, we investigated whether individuals with RLS show differences in social cognitio…

Background Parkinson’s disease (PD) progression is clinically heterogeneous, complicating predictive modeling and personalized monitoring. We developed a protein-peptide sequential convolutional neural network (pSCNN) enhanced with kernel density estimation (KDE) to capture nonlinear relationships between cerebrospina…