VCAM1 (T-1591C and T-833C) and E-selectin S128R polymorphisms are not risk factors for Hashimoto’s thyroiditis

OpenAlex · English

Aim: The etiopathogenesis of Hashimoto’s thyroiditis (HT) has not been clearly elucidated although the role of chronical inflammation and endothelial dysfunction has been established. Adhesion molecules such as vascular cell adhesion molecule1 (VCAM1) and E-selectin are secreted from vascular endothelium and promote accummulation of leukocytes in damaged endothelial areas. This study examined the possible association of VCAM1 (T-1591C and T-833C) and E-selectin S128R single nucleotide polymorphisms (SNPs) with the occurence of HT for the first time. Methods: VCAM1 (T-1591C and T-833C), and E-selectin S128R SNPs in DNA from peripheral blood leukocytes of 189 patients with HT and 247 healthy controls were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. Results: We did not find significant differences in the distributions of studied polymorphisms between patients with HT and healthy controls. Conclusions: The results of present study suggest that VCAM1 (T-1591C and T-833C) and E-selectin S128R SNPs may not be risk factors for HT. For all that; further studies with a larger cohort, analyzing other polymorphisms in VCAM1 and E-selectin genes are necessary to support our observations.