Effect of 2100 MHz Radio Frequency Radiation on Oxidative Stress on Testicular Tissue of Hypertensive and Non-Hypertensive Rats

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INTRODUCTION:Nowadays exposure to radiation has been increasing with the advancement of technology.Although considerable research has focused on the effects of radiation exposure on biological systems, its effect on hypertensives has previously never been addressed.In this study, the effect of 2100 MHz radio frequency radiation (RFR) on oxidative stress on testicular tissue of hypertensive and non-hypertensive rats is aimed to be investigated.METHODS: Twenty-four male Wistar Albino rats were allocated into four groups: 1) Control (C), 2) Control +Hypertension (C+H), 3) Radiation (R), 4) Hypertension+ Radiation (H+R).In order to induce hypertension in rats, 60 mg/kg L-NAME dissolved in 1 ml tap water was orally administered to rats for one month.Rats were exposed to 2100 MHz RFR for 60 min /day, 5 days/ week for 8 weeks.Following the experiments, the rats were decapitated under anesthesia and malondialdehyde (MDA), Nitrite+nitrate (NOx) and glutathione (GSH) levels were examined on testicular tissue.Results were compared with One-way ANOVA followed by post hoc Tukey tests.Values of p<0.05 were accepted as significant.RESULTS: When testicular tissues of R and H+R groups were compared with those of C and H groups, MDA and NOx levels were seen to increase while GSH levels decreased (p<0.01).DISCUSSION AND CONCLUSION: Radiation exposure led to an equal amount of increase of oxidative stress on testicular tissues of hypertensive and non-hypertensive rats.Oxidative stress caused by radiation exposure may negatively affect male reproductive system in both hypertensives and non-hypertensives.