Primary Gallbladder Pleomorphic Sarcoma: A Rare Case

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Primary gallbladder pleomorphic sarcoma is a very rarely seen type of tumor and its prognosis is not well known mainly due to the limited number of cases reported.Here, we present a case with primary gallbladder pleomorphic sarcoma of which diagnosis was based on morphology and immunohistochemistry.A 70-year-old male presented with three months of abdominal pain in the upper right quadrant and weight loss.The patient reported a past medical history of chronic cholecystitis.Using abdominal magnetic resonance imaging (MRI), the patient was diagnosed with gallbladder cancer.Radical cholecystectomy, with segment 4b and 5 resection of the underlying liver tissue and dissection of the pericholedochal lymph nodes were performed.Patient's postoperative course was unremarkable and he was discharged on the postoperative 5 th day.The immunohistochemical analyses supported the diagnosis of primary gallbladder pleomorphic sarcoma.The patient was referred to the department medical oncology for adjuvant chemotherapy Primary gallbladder pleomorphic sarcoma is a very rare histological type with an unclear pathogenesis.A better understanding of pathogenesis and treatment for this disease, with the larger case series may be better addressed.