Article detail · 2024
Interleukin-21 and Interleukin-23 levels in familial Mediterranean Fever before and after treatment: the role of cytokines in disease pathogenesis
- Year
- 2024
- Type
- article
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- YÖKSİS YÖKSİS article record
- YÖKSİS venue Scientific Reports
- Catalog match (ISSN) Scientific Reports
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Abstract
OpenAlex · English
In a previous study, it has been shown that the population of Th17 lymphocytes was increased in patients with FMF. IL-21 and IL-23 play significant roles in the production and differentiation of Th17 cells. In this study, we aimed to evaluate serum levels of IL-21 and IL-23 in FMF patients both at diagnosis and after treatment, and to compare these levels with those of healthy controls. Twenty-seven newly diagnosed patients with FMF in attack-free periods and twenty-seven healthy volunteers enrolled in the study. The groups were comparable with respect to age and gender. IL-21 and IL-23 levels in serum samples from patients at the time of diagnosis, in remission after treatment, and from the control groups were analysed using the ELISA method. There was no significant difference between the cytokine levels of the patient group at the time of diagnosis and the cytokine levels of the control group (for IL-21, p: 0.28 and for IL-23, p: 0.56). Similarly, there was no significant difference between the patients' cytokine levels at the time of diagnosis and after treatment (for IL-21, p: 0.99 and for IL-23, p: 0.08). Interleukin levels at the time of diagnosis did not differ among patient groups based on the presence of clinical findings or the M694V genotype. Our results suggest that IL-21 and IL-23 do not play a role in the pathogenesis of the disease. However, while interpreting these findings, it should be considered that patients with active episodes were excluded and cytokine levels were not measured in tissue samples.
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3 citations
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3 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Caspase 3, Caspase 8, Caspase 9, Granzyme-B and Apaf-1 Levels in Familial Mediterranean Fever Patients Treated with Colchicine: Experimental and Theoretical Methods 2025
- Caspase 3, Caspase 8, Caspase 9, Granzyme-B and Apaf-1 Levels in Familial Mediterranean Fever Patients Treated with Colchicine: Experimental and Theoretical Methods 2025
- Caspase 3, Caspase 8, Caspase 9, Granzyme-B and Apaf-1 Levels in Familial Mediterranean Fever Patients Treated with Colchicine: Experimental and Theoretical Methods 2025