Article detail · 2023
Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease
Journal
Insights ImagingISSN 10.1186/s13244-023-01390-0
- Year
- 2023
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Insights Imaging
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: Magnetic resonance elastography (MRE) has been used to stage liver fibrosis in adults. We aimed to assess the agreement between the Ishak scoring system and magnetic resonance elastography-measured liver stiffness (MRE-LS) in children. This study included all the children who underwent abdominal MRE and liver biopsies between February 2018 and January 2021. The correlation between MRE-LS and Ishak fibrosis stage, MRE parameters, and clinical and biochemical markers affecting this relationship was investigated. RESULTS: A total of 52 patients (31 male; a median age of 11.8 years) were included in the study. The MRE-LS values were significantly different between Ishak fibrosis stages (p = 0.036). With a cut-off value of 2.97 kilopascals, MRE-LS had sensitivity, specificity, PPV, NPV and accuracy values of 90.9%, 82.9%, 58.8%, 97.1%, and 84.6%, respectively, for differentiating mild/moderate fibrosis (F0, 1, 2, 3) from severe fibrosis (F ≥ 4). Although MRE-LS was moderately correlated with Ishak fibrosis score and histological activity index and weakly correlated with aspartate aminotransferase, hepatic steatosis, and R2*, only Ishak fibrosis score was a significant predictor of MRE-LS. MRE-measured spleen stiffness was weakly correlated with the Ishak fibrosis score. CONCLUSIONS: MRE has high sensitivity and specificity for evaluating liver fibrosis in children. MRE may be used to evaluate liver fibrosis in pediatric patients.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
8 citations
OpenAlex cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2024
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children 2023