Article detail · 2012
GSTP1 Gene Methylation Profiles in Helicobacter pylori () and (-) Antral Intestinal Metaplasia and Distal Gastric Tumour Patients in Turkish Population
Journal
HepatogastroenterologyISSN 0172-6390
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2012
- DOI
- 10.5754/hge12148
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Hepatogastroenterology
- Catalog match (ISSN) Hepato-Gastroenterology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND/AIMS: Gastric cancer (GC) is the second most common malignancy worldwide, with a high mortality rate. The incidence of GC has declined in the western countries during the last decades. The glutathione S-transferases comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study we aimed at the relationship GSTP-1 methylation in patients with intestinal metaplasia with and without Helicobacter pylori infection, gastric cancer and controls. METHODOLOGY: The methylation status of GSTP1 gene was analyzed by methylation specific PCR after bisulfate modification in H. pylori (+) (n=25) and (-) (n=25) intestinal metaplasia (IM) patients, GC (n=25) and control subjects (n=15) between September 2009 to November 2011. RESULTS: During the study period 90 patients who underwent endoscopic examination were included in the study. When we considered the GSTP1 gene methylation profile in all of the groups; 26 (28%)patients had methylated GSTP1 gene, 31 (34%) patients had unmethylated GSTP1 gene and 33 (36%) patients had heterogeneously methylated GSTPI gene. CONCLUSIONS: GSTP1 gene methylation profile is not appropriate for early diagnosis of cases with gastric cancer.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
3 citations
OpenAlex cited_by_count (cache / database)
6 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer 2012
- The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer 2012
- The role of Helicobacter pylori and NSAIDs in thr Pathogenesis of Uncomplicated Duodenal Ulcer 2012
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- RELATIONSHIP BETWEEN PEDIATRIC CELIAC DISEASE AND CHROMATIN REMODELING GENE EXPRESSIONS 2022