The Relationship Between Insulin Resistance and Serum Preptin Level

English (OpenAlex)

Objectives: Preptin is derived from e-peptide of proinsulin-like growth factor II, is present in islet β-cell granules and is co-secreted with insulin in response to glucose. Studies have suggested that preptin plays a role in glucose and lipid metabolism. In this study, we have investigated the serum preptin levels in patient with insulin resistance (IR) and by this way, we aimed to define the role of preptin as a parameter in early diagnosis and monitoring progression of diabetes. Materials and Methods: The study included 49 IR patients and 37 healthy controls. The presence of IR was based on the Homeostatic model of assessment- insulin resistance (HOMA-IR) level of 2.7 or higher. Fasting plasma samples were obtained from the patients and the control group. The serum levels of preptin were measured with an Enzyme-Linked Immuno Sorbent Assay (ELISA)kit. Results: The IR patients had higher fasting insulin, HOMA-IR and triglyceride levels than the control subjects (p < 0.01). And the serum levels of preptin were significantly higher in IR patients than in the healthy controls (492.00±289.23 and 98.41±50.64 respectively; p<0.01). They showed a positive correlation with the HOMA-IR (r=0.43; p<0.01), the fasting insulin level (r=0.64; p<0.001), body mass index count (r=0.41; p<0.01) and triglyceride level (r=0.26; p<0.05). Conclusion: The serum preptin level was higher in patients with IR. These findings demonstrate that there is a potential link between preptin and glucose-lipid metabolism. In conclusion, high preptin levels in patients with insulin resistance suggest that preptin may play a role in the pathogenesis of insulin resistance.